Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1469-0691.2011.03606.x
Title: The impact of multidrug resistance in healthcare-associated and nosocomial Gram-negative bacteraemia on mortality and length of stay: Cohort study
Authors: Lye, D.C.
Earnest, A. 
Ling, M.L.
Lee, T.-E.
Yong, H.-C.
Fisher, D.A.
Krishnan, P.
Hsu, L.-Y.
Keywords: Antimicrobial drug resistance
Cohort study
Gram-negative bacteraemia
Length of stay
Mortality
Issue Date: May-2012
Citation: Lye, D.C., Earnest, A., Ling, M.L., Lee, T.-E., Yong, H.-C., Fisher, D.A., Krishnan, P., Hsu, L.-Y. (2012-05). The impact of multidrug resistance in healthcare-associated and nosocomial Gram-negative bacteraemia on mortality and length of stay: Cohort study. Clinical Microbiology and Infection 18 (5) : 502-508. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1469-0691.2011.03606.x
Abstract: Multidrug-resistant Gram-negative bacteria (MDR-GNB) are an emerging public health threat. Accurate estimates of their clinical impact are vital for justifying interventions directed towards preventing or managing infections caused by these pathogens. A retrospective observational cohort study was conducted between 1 January 2007 and 31 July 2009, involving subjects with healthcare-associated and nosocomial Gram-negative bacteraemia at two large Singaporean hospitals. Outcomes studied were mortality and length of stay post-onset of bacteraemia in survivors (LOS). There were 675 subjects (301 with MDR-GNB) matching study inclusion criteria. On multivariate analysis, multidrug resistance was not associated with 30-day mortality, but it was independently associated with longer LOS in survivors (coefficient, 0.34; 95% CI, 0.21-0.48; p
Source Title: Clinical Microbiology and Infection
URI: http://scholarbank.nus.edu.sg/handle/10635/110313
ISSN: 1198743X
DOI: 10.1111/j.1469-0691.2011.03606.x
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