Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cellsig.2014.01.017
Title: Stratification and delineation of gastric cancer signaling by in vitro transcription factor activity profiling and integrative genomics
Authors: Periasamy, J.
Muthuswami, M.
Rao, D.B.
Tan, P. 
Ganesan, K.
Keywords: Gastric cancer
In vitro profiling
Integrative functional genomics
Signaling pathway
Transcription factor
Issue Date: May-2014
Citation: Periasamy, J., Muthuswami, M., Rao, D.B., Tan, P., Ganesan, K. (2014-05). Stratification and delineation of gastric cancer signaling by in vitro transcription factor activity profiling and integrative genomics. Cellular Signalling 26 (5) : 880-894. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cellsig.2014.01.017
Abstract: Integrative functional genomic approaches are helpful in delineating the complex dysregulations in cancers. In the present study, in vitro activity profiling of 45 signaling pathway driven transcription factors in eight gastric cancer cell lines and direct comparison with genome-wide profiles of gastric tumors were performed and the integration resulted in the identification of three categories of factors/pathways: i) highly activated signaling pathways that stem from mutations are the critical oncogenic drivers, ii) constitutively activated stress responsive pathways which are activated not due to genetic alterations, and iii) consistently down-regulated nuclear receptor responsive factors. This functional profiling helps in discriminating therapeutic targets and signaling interactions. © 2014 Elsevier Inc.
Source Title: Cellular Signalling
URI: http://scholarbank.nus.edu.sg/handle/10635/110290
ISSN: 08986568
DOI: 10.1016/j.cellsig.2014.01.017
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