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|Title:||Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance||Authors:||De Havas, J.A.
Default mode network
|Issue Date:||16-Jan-2012||Citation:||De Havas, J.A., Parimal, S., Soon, C.S., Chee, M.W.L. (2012-01-16). Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance. NeuroImage 59 (2) : 1745-1751. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuroimage.2011.08.026||Abstract:||Sleep deprivation (SD) can alter extrinsic, task-related fMRI signal involved in attention, memory and executive function. However, its effects on intrinsic low-frequency connectivity within the Default Mode Network (DMN) and its related anti-correlated network (ACN) have not been well characterized. We investigated the effect of SD on functional connectivity within the DMN, and on DMN-ACN anti-correlation, both during the resting state and during performance of a visual attention task (VAT). 26 healthy participants underwent fMRI twice: once after a normal night of sleep in rested wakefulness (RW) and once following approximately 24. h of total SD. A seed-based approach was used to examine pairwise correlations of low-frequency fMRI signal across different nodes in each state. SD was associated with significant selective reductions in DMN functional connectivity and DMN-ACN anti-correlation. This was congruent across resting state and VAT analyses, suggesting that SD induces a robust alteration in the intrinsic connectivity within and between these networks. © 2011 Elsevier Inc.||Source Title:||NeuroImage||URI:||http://scholarbank.nus.edu.sg/handle/10635/110276||ISSN:||10538119||DOI:||10.1016/j.neuroimage.2011.08.026|
|Appears in Collections:||Staff Publications|
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