Please use this identifier to cite or link to this item: https://doi.org/10.1097/JCP.0b013e31820ebd2c
Title: Residual symptoms in depressed outpatients who respond by 50% but do not remit to antidepressant medication
Authors: McClintock, S.M.
Husain, M.M.
Wisniewski, S.R.
Nierenberg, A.A.
Stewart, J.W.
Trivedi, M.H.
Cook, I.
Morris, D.
Warden, D.
Rush, A.J. 
Keywords: D
depression
residual
STAR
symptoms
treatment response
Issue Date: Apr-2011
Citation: McClintock, S.M., Husain, M.M., Wisniewski, S.R., Nierenberg, A.A., Stewart, J.W., Trivedi, M.H., Cook, I., Morris, D., Warden, D., Rush, A.J. (2011-04). Residual symptoms in depressed outpatients who respond by 50% but do not remit to antidepressant medication. Journal of Clinical Psychopharmacology 31 (2) : 180-186. ScholarBank@NUS Repository. https://doi.org/10.1097/JCP.0b013e31820ebd2c
Abstract: Little is known about the quantity or quality of residual depressive symptoms in patients with major depressive disorder (MDD) who have responded but not remitted with antidepressant treatment. This report describes the residual symptom domains and individual depressive symptoms in a large representative sample of outpatients with nonpsychotic MDD who responded without remitting after up to 12 weeks of citalopram treatment in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Response was defined as 50% or greater reduction in baseline 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR16) by treatment exit, and remission as a final QIDS-SR16 of less than 6. Residual symptom domains and individual symptoms were based on the QIDS-SR16 and classified as either persisting from baseline or emerging during treatment. Most responders who did not remit endorsed approximately 5 residual symptom domains and 6 to 7 residual depressive symptoms. The most common domains were insomnia (94.6%), sad mood (70.8%), and decreased concentration (69.6%). The most common individual symptoms were midnocturnal insomnia (79.0%), sad mood (70.8%), and decreased concentration/decision making (69.6%). The most common treatment-emergent symptoms were midnocturnal insomnia (51.4%) and decreased general interest (40.0%). The most common persistent symptoms were midnocturnal insomnia (81.6%), sad mood (70.8%), and decreased concentration/decision making (70.6%). Suicidal ideation was the least common treatment-emergent symptom (0.7%) and the least common persistent residual symptom (17.1%). These findings suggest that depressed outpatients who respond by 50% without remitting to citalopram treatment have a broad range of residual symptoms. Individualized treatments are warranted to specifically address each patient's residual depressive symptoms. © 2011 Lippincott Williams & Wilkins.
Source Title: Journal of Clinical Psychopharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/110251
ISSN: 02710749
DOI: 10.1097/JCP.0b013e31820ebd2c
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

139
checked on Dec 2, 2022

WEB OF SCIENCETM
Citations

126
checked on Dec 2, 2022

Page view(s)

174
checked on Nov 24, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.