Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10096-011-1351-6
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dc.titleProspective audit and feedback on antibiotic prescription in an adult hematology-oncology unit in Singapore
dc.contributor.authorYeo, C.-L.
dc.contributor.authorChan, D.S.-G.
dc.contributor.authorEarnest, A.
dc.contributor.authorWu, T.-S.
dc.contributor.authorYeoh, S.-F.
dc.contributor.authorLim, R.
dc.contributor.authorJureen, R.
dc.contributor.authorFisher, D.
dc.contributor.authorHsu, L.-Y.
dc.date.accessioned2014-11-26T08:30:04Z
dc.date.available2014-11-26T08:30:04Z
dc.date.issued2012-04
dc.identifier.citationYeo, C.-L., Chan, D.S.-G., Earnest, A., Wu, T.-S., Yeoh, S.-F., Lim, R., Jureen, R., Fisher, D., Hsu, L.-Y. (2012-04). Prospective audit and feedback on antibiotic prescription in an adult hematology-oncology unit in Singapore. European Journal of Clinical Microbiology and Infectious Diseases 31 (4) : 583-590. ScholarBank@NUS Repository. https://doi.org/10.1007/s10096-011-1351-6
dc.identifier.issn09349723
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110232
dc.description.abstractWe evaluated the impact of a prospective audit and feedback antimicrobial stewardship program (ASP) on antibiotic prescription and resistance trends in a hematology-oncology unit in a university hospital (National University Cancer Institute, Singapore [NCIS]). A prospective interrupted time-series study comprising 11-month pre-intervention (PIP) and intervention evaluation phases (IEP) flanking a one-month implementation phase was carried out. Outcome measures included defined daily dose per 100 (DDD/100) inpatient-days of ASP-audited and all antibiotics (encompassing audited and non-audited antibiotics), and the incidence-density of antibiotic-resistant microorganisms at the NCIS. Internal and external controls were DDD/100 inpatient-days of paracetamol at the NCIS and DDD/100 inpatient-days of antibiotics prescribed in the rest of the hospital. There were 580 ASP recommendations from 1,276 audits, with a mean monthly compliance of 86.9%. Significant reversal of prescription trends towards reduced prescription of audited (coefficient=-2.621; 95% confidence interval [CI]: -4.923, -0.319; p=0.026) and all evaluated antibiotics (coefficient=-4.069; 95% CI: -8.075, -0.063; p=0.046) was observed. No changes were seen for both internal and external controls, except for the reversal of prescription trends for cephalosporins hospital-wide. Antimicrobial resistance did not change over the time period of the study. Adverse outcomes - the majority unavoidable - occurred following 5.5% of accepted ASP recommendations. Safe and effective ASPs can be implemented in the complex setting of hematology-oncology inpatients. © Springer-Verlag 2011.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s10096-011-1351-6
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1007/s10096-011-1351-6
dc.description.sourcetitleEuropean Journal of Clinical Microbiology and Infectious Diseases
dc.description.volume31
dc.description.issue4
dc.description.page583-590
dc.description.codenEJCDE
dc.identifier.isiut000301659800028
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