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Title: Preserved working memory and altered brain activation in persons at risk for psychosis
Authors: Yaakub, S.N.
Dorairaj, K.
Poh, J.S.
Asplund, C.L.
Krishnan, R. 
Lee, J.
Keefe, R.S.E.
Adcock, R.A.
Wood, S.J.
Chee, M.W.L. 
Issue Date: 1-Nov-2013
Citation: Yaakub, S.N., Dorairaj, K., Poh, J.S., Asplund, C.L., Krishnan, R., Lee, J., Keefe, R.S.E., Adcock, R.A., Wood, S.J., Chee, M.W.L. (2013-11-01). Preserved working memory and altered brain activation in persons at risk for psychosis. American Journal of Psychiatry 170 (11) : 1297-1307. ScholarBank@NUS Repository.
Abstract: Objective: Patients with schizophrenia exhibit impairments in working memory that often appear in attenuated formin persons at high risk for the illness. The authors hypothesized that deviations in task-related brain activation and deactivation would occur in persons with an at-risk mental state performing a working memory task that entailed the maintenance and manipulation of letters. Method: Participants at ultra high risk for developing psychosis (N=60), identified using the Comprehensive Assessment of At-Risk Mental States, and healthy comparison subjects (N=38) 14 to 29 years of age underwent functional MRI while performing a verbal working memory task. Group differences in brain activation were identified using analysis of covariance. Results: The two groups did not show significant differences in speed or accuracy of performance, even after accounting for differences in education. Irrespective of task condition, at-risk participants exhibited significantly less activation than healthy comparison subjects in the left anterior insula. During letter manipulation, at-risk persons exhibited greater task-related deactivation within the defaultmode network than comparison subjects. Region-of-interest analysis in the at-risk group revealed significantly greater right dorsolateral prefrontal cortex activation during manipulation of letters. Conclusions: Despite comparable behavioral performance, at-risk participants performing a verbal working memory task exhibited altered brain activation compared with healthy subjects. These findings demonstrate an altered pattern of brain activation in at-risk persons that contains elements of reduced function as well as compensation.
Source Title: American Journal of Psychiatry
ISSN: 0002953X
DOI: 10.1176/appi.ajp.2013.12081135
Appears in Collections:Staff Publications

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