Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0044206
Title: MiR-214 Targets β-Catenin Pathway to Suppress Invasion, Stem-Like Traits and Recurrence of Human Hepatocellular Carcinoma
Authors: Xia, H.
Ooi, L.L.P.J.
Hui, K.M. 
Issue Date: 4-Sep-2012
Citation: Xia, H., Ooi, L.L.P.J., Hui, K.M. (2012-09-04). MiR-214 Targets β-Catenin Pathway to Suppress Invasion, Stem-Like Traits and Recurrence of Human Hepatocellular Carcinoma. PLoS ONE 7 (9) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0044206
Abstract: The down-regulation of miR-214 has previously been observed in human hepatocellular carcinoma (HCC). Here, we demonstrated the down-regulation of miR-214 is associated with cell invasion, stem-like traits and early recurrence of HCC. Firstly, we validated the suppression of miR-214 in human HCC by real-time quantitative RT-PCR (qRT-PCR) in 20 paired tumor and non-tumor liver tissues of HCC patients and 10 histologically normal liver tissues from colorectal cancer patients with liver metastases. Further qRT-PCR analysis of 50 HCC tissues from an independent cohort of HCC patients of whom 29 with early recurrent disease (
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/110177
ISSN: 19326203
DOI: 10.1371/journal.pone.0044206
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