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Title: Hyperbaric oxygen therapy in necrotising soft tissue infections: A study of patients in the United States Nationwide Inpatient Sample
Authors: Soh, C.R.
Pietrobon, R. 
Freiberger, J.J.
Chew, S.T.
Rajgor, D.
Gandhi, M.
Shah, J. 
Moon, R.E.
Keywords: Healthcare cost and utilisation project
Hyperbaric oxygen therapy
National inpatient sample
Necrotising soft tissue infections
Issue Date: Jul-2012
Citation: Soh, C.R., Pietrobon, R., Freiberger, J.J., Chew, S.T., Rajgor, D., Gandhi, M., Shah, J., Moon, R.E. (2012-07). Hyperbaric oxygen therapy in necrotising soft tissue infections: A study of patients in the United States Nationwide Inpatient Sample. Intensive Care Medicine 38 (7) : 1143-1151. ScholarBank@NUS Repository.
Abstract: Purpose: Necrotising soft tissue infection (NSTI) is a deadly disease associated with a significant risk of mortality and long-term disability from limb and tissue loss. The aim of this study was to determine the effect of hyperbaric oxygen (HBO 2) therapy on mortality, complication rate, discharge status/location, hospital length of stay and inflation-adjusted hospitalisation cost in patients with NSTI. Methods: This was a retrospective study of 45,913 patients in the Nationwide Inpatient Sample (NIS) from 1988 to 2009. Results: A total of 405 patients received HBO 2 therapy. The patients with NSTI who received HBO 2 therapy had a lower mortality (4.5 vs. 9.4 %, p = 0.001). After adjusting for predictors and confounders, patients who received HBO 2 therapy had a statistically significantly lower risk of dying (odds ratio (OR) 0.49, 95 % confidence interval (CI) 0.29-0.83), higher hospitalisation cost (US$52,205 vs. US$45,464, p = 0.02) and longer length of stay (LOS) (14.3 days vs. 10.7 days, p < 0.001). Conclusions: This retrospective analysis of HBO 2 therapy in NSTI showed that despite the higher hospitalisation cost and longer length of stay, the statistically significant reduction in mortality supports the use of HBO 2 therapy in NSTI. © 2012 Copyright jointly held by Springer and ESICM.
Source Title: Intensive Care Medicine
ISSN: 03424642
DOI: 10.1007/s00134-012-2558-4
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