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Title: Genomic and molecular characterization of alzheimer disease
Authors: Lee, T.-S. 
Chua, S.-M.
Ly, P.
Song, W.
Keywords: Alzheimer disease
Gene-environment interaction
Gene-wide association studies
Issue Date: May-2010
Citation: Lee, T.-S., Chua, S.-M., Ly, P., Song, W. (2010-05). Genomic and molecular characterization of alzheimer disease. Current Psychiatry Reviews 6 (2) : 104-113. ScholarBank@NUS Repository.
Abstract: Alzheimer disease (AD) is the most common neurodegenerative disease that afflicts mankind. Tremendous efforts have been made in investigating the genetic underpinnings and molecular pathophysiology of this illness. The heritability of AD is estimated to be around 60% and about 5% of AD cases are familial with early-onset caused by gene mutations. Several genes including APP, PSEN1, PSEN2 and APOE e4 have been identified to be causative or associated with AD. This is an overview of AD from the perspective of some of the latest high throughput technological platforms, including genome-wide association studies (GWAS), transcriptomics, proteomics, metabolomics and epigenetics. These approaches are introduced briefly followed by discussion of some of the more significant endeavors and findings. These results, including putative gene loci, differentially expressed genes, epigenetic effects etc., may provide some of the pieces of the AD puzzle. However a systems approach towards the diverse findings from various platforms will most likely give us a quantum leap in the understanding of AD that should lead to breakthroughs in diagnosis, tracking the disease progress, drug discovery and development. © 2010 Bentham Science Publishers Ltd.
Source Title: Current Psychiatry Reviews
ISSN: 15734005
DOI: 10.2174/157340010791196493
Appears in Collections:Staff Publications

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