Please use this identifier to cite or link to this item: https://doi.org/10.2147/OPTH.S50584
Title: De novo ocular hypertension after Descemet stripping endothelial keratoplasty: Comparative 3-year incidence, risk factors, and outcomes
Authors: Chan, E.W.
Wong, T.T.
Htoon, H.M.
Ho, C.L.
Tan, D.T.
Mehta, J.S. 
Keywords: DSAEK
Glaucoma
Ocular hypertension
Risk factors
Issue Date: 17-Sep-2013
Citation: Chan, E.W., Wong, T.T., Htoon, H.M., Ho, C.L., Tan, D.T., Mehta, J.S. (2013-09-17). De novo ocular hypertension after Descemet stripping endothelial keratoplasty: Comparative 3-year incidence, risk factors, and outcomes. Clinical Ophthalmology 7 : 1829-1841. ScholarBank@NUS Repository. https://doi.org/10.2147/OPTH.S50584
Abstract: Objective: To compare the 3-year incidence of de novo ocular hypertension (OHT) after Descemet stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK). For DSAEK, to evaluate predictors for OHT and 2-year outcomes after OHT development. Methods: This was a review of the prospective Singapore Corneal Transplant Study at a single tertiary referral center. Consecutive DSAEKs and PKs for Fuchs' endothelial dystrophy (FED) and pseudophakic bullous keratopathy (PBK) in eyes without pre-existing glaucoma were analyzed. OHT incidence after DSAEK and PK were compared using Kaplan-Meier survival analysis, and OHT risk factors identified using Cox proportional regression. OHT was defined: intraocular pressure (IOP) ≥ 24 mmHg or ≥ 10 mmHg from baseline. Secondary outcomes 2 years after OHT development in DSAEK were rates of glaucoma medical therapy failure, IOP success, graft failure and rejection, and best-spectacle corrected visual acuity (BSCVA). Results: There were 108 (96.4%) DSAEKs and 216 (96%) PKs. The 1-, 2 and 3-year de novo OHT incidence was not significantly different between DSAEK (36.1%, 47.2%, 47.2%, respectively) and PK (35.7%, 44.9%, 45.8%, respectively; P = 0.914). OHT incidence did not differ in subgroup analyses of multiple clinical variables (P.>0.1). OHT predictors after DSAEK were: fellow eye glaucoma (hazard ratio [HR] 3.20, P=0.004), age,
Source Title: Clinical Ophthalmology
URI: http://scholarbank.nus.edu.sg/handle/10635/110005
ISSN: 11775467
DOI: 10.2147/OPTH.S50584
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