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|dc.title||Clinical features of depression in Asia: Results of a large prospective, cross-sectional study|
|dc.identifier.citation||Srisurapanont, M., Hong, J.P., Tian-mei, S., Hatim, A., Liu, C.-Y., Udomratn, P., Bae, J.N., Fang, Y., Chua, H.C., Liu, S.-I., George, T., Bautista, D., Chan, E., Rush, A.J. (2013-12). Clinical features of depression in Asia: Results of a large prospective, cross-sectional study. Asia-Pacific Psychiatry 5 (4) : 259-267. ScholarBank@NUS Repository. https://doi.org/10.1111/appy.12104|
|dc.description.abstract||Introduction: The objective of this study was to investigate the clinical features of depression in Asian patients. Methods: It was a cross-sectional, observational study of depression in China, Korea, Malaysia, Singapore, Taiwan, and Thailand. Participants were drug-free outpatients with depressed mood and/or anhedonia. Symptoms and clinical features were assessed using the Montgomery-Asberg Depression Rating Scale, Symptoms Checklist 90-Revised (SCL-90-R), and the Fatigue Severity Scale. Other measures included the Medical Outcome Survey 36-Item Short-Form Health Survey (SF-36), the Sheehan Disability Scale, and the Multidimensional Scale of Perceived Social Support (MSPSS). Results: A total of 547 outpatients with major depressive disorder were included in the analyses. Among the Montgomery-Asberg Depression Rating Scale symptoms, "reported sadness" and "reduced sleep" had the highest severity, with means (SDs) of 3.4 (1.2) and 3.4 (1.6), respectively. Apart from the SCL-90-R depression and anxiety domains, the SCL-90-R obsession-compulsion syndrome had the highest domain score, with a mean (SD) of 1.9 (0.9). Among eight domains, the mean (SD) SF-36 pain subscale score of 58.4 (27.7) was only second to that for the SF-36 physical function. In comparison to other disability domains, the Sheehan Disability Scale work/school had the highest subscale score, with a mean (SD) of 6.5 (2.9). The mean (SD) MSPSS "family" subscale score of 4.7 (1.7) was higher than the MSPSS "friends" and "significant others" subscale scores. Discussion: This study suggests that pain has a minimal impact on the quality of life in Asian patients with depression. Noteworthy issues in this population may include insomnia, obsessive-compulsive symptoms, working/school disability, and family support. © 2013 Wiley Publishing Asia Pty Ltd.|
|dc.contributor.department||DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE|
|dc.contributor.department||INSTITUTE OF MOLECULAR & CELL BIOLOGY|
|Appears in Collections:||Staff Publications|
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