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Title: Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese
Authors: Tan, E.K. 
Lu, C.S.
Peng, R.
Teo, Y.Y.
Wu-Chou, Y.H.
Chen, R.S.
Weng, Y.H.
Chen, C.M.
Fung, H.C.
Tan, L.C.
Zhang, Z.J.
An, X.K.
Lee-Chen, G.J.
Lee, M.C.
Fook-Chong, S.
Burgunder, J.M.
Wu, R.M.
Wu, Y.R.
Keywords: Parkinson's disease
Issue Date: Dec-2010
Citation: Tan, E.K., Lu, C.S., Peng, R., Teo, Y.Y., Wu-Chou, Y.H., Chen, R.S., Weng, Y.H., Chen, C.M., Fung, H.C., Tan, L.C., Zhang, Z.J., An, X.K., Lee-Chen, G.J., Lee, M.C., Fook-Chong, S., Burgunder, J.M., Wu, R.M., Wu, Y.R. (2010-12). Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese. Neurobiology of Aging 31 (12) : 2194-2196. ScholarBank@NUS Repository.
Abstract: The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD. © 2008 Elsevier Inc.
Source Title: Neurobiology of Aging
ISSN: 01974580
DOI: 10.1016/j.neurobiolaging.2008.11.008
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