Please use this identifier to cite or link to this item: https://doi.org/10.2174/092986709788612710
DC FieldValue
dc.titleMetabotropic glutamate receptors in the control of neuronal activity and as targets for development of anti-epileptogenic drugs
dc.contributor.authorTang, F.R.
dc.contributor.authorBradford, H.F.
dc.contributor.authorLing, E.-A.
dc.date.accessioned2014-11-26T07:50:39Z
dc.date.available2014-11-26T07:50:39Z
dc.date.issued2009
dc.identifier.citationTang, F.R., Bradford, H.F., Ling, E.-A. (2009). Metabotropic glutamate receptors in the control of neuronal activity and as targets for development of anti-epileptogenic drugs. Current Medicinal Chemistry 16 (17) : 2189-2204. ScholarBank@NUS Repository. https://doi.org/10.2174/092986709788612710
dc.identifier.issn09298673
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109850
dc.description.abstractThe anticonvulsant and neuroprotective properties of agonist and antagonist of metabotropic glutamate receptors (mGluRs) have been known for 15 years or so. However, it is not yet clear whether these agents, and allied compounds, can be considered as candidate drugs for eventual use in the clinic to control the development of epilepsy, (i.e. as anti-epileptogenics), or for the control of seizures themselves (i.e. as anticonvulsants). In fact, few studies have been designed to test for these properties by, for instance, administering these agents during the chronic stages of experimental epilepsy to determine whether a tendency to generate spontaneously recurrent seizures, which often appear by epileptogenesis, could be prevented or stopped. Even in the acute stages, there are substantial differences in experimental design between the published studies. Thus, there are large variations in such factors as timing, and the route of administration of candidate drugs, the age, or species and strain of experimental animal used, and the experimental epilepsy model employed. Such variations often make it difficult to accurately assess the anticonvulsant, neuroprotective and antiepileptogenic properties of each candidate drug across a wide range of studies. This paper, will review neuroanatomical, neurochemical, neuropharmacological studies of mGluRs in animal models and in patients with temporal lobe epilepsy, and summarize anticonvulsive and neuroprotective effects of their agonists and antagonists in different seizure and epilepsy models in order to give direction for the development of new generation antiepileptogenic and anticonvulsive drugs. © 2009 Bentham Science Publishers Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2174/092986709788612710
dc.sourceScopus
dc.subjectAgonists and antagonists
dc.subjectAnti-epileptogenic
dc.subjectAnticonvulsive
dc.subjectGlutamate-induced epileptic discharges
dc.subjectMetabotropic glutamate receptors (mGluRs)
dc.typeReview
dc.contributor.departmentANATOMY
dc.description.doi10.2174/092986709788612710
dc.description.sourcetitleCurrent Medicinal Chemistry
dc.description.volume16
dc.description.issue17
dc.description.page2189-2204
dc.description.codenCMCHE
dc.identifier.isiut000267014900005
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

15
checked on Nov 26, 2020

WEB OF SCIENCETM
Citations

12
checked on Nov 26, 2020

Page view(s)

107
checked on Nov 28, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.