Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00109-010-0709-z
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dc.titleEmerging therapeutic approaches in the management of retinal angiogenesis and edema
dc.contributor.authorTruong, A.
dc.contributor.authorWong, T.Y.
dc.contributor.authorKhachigian, L.M.
dc.date.accessioned2014-11-26T07:50:30Z
dc.date.available2014-11-26T07:50:30Z
dc.date.issued2011-04
dc.identifier.citationTruong, A., Wong, T.Y., Khachigian, L.M. (2011-04). Emerging therapeutic approaches in the management of retinal angiogenesis and edema. Journal of Molecular Medicine 89 (4) : 343-361. ScholarBank@NUS Repository. https://doi.org/10.1007/s00109-010-0709-z
dc.identifier.issn09462716
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109836
dc.description.abstractConditions resulting in retinal angiogenesis and edema (exudative age-related macular degeneration, diabetic retinopathy, retinal vein occlusion and retinopathy of prematurity) are major causes of visual impairment, with significant impact on quality of life. There has been increasing clinical usage of anti-vascular endothelial growth factor (anti-VEGF) agents to stop retinal angiogenesis and resolve intraretinal fluid arising from these conditions. However, anti-VEGFs have not been completely successful in curing these conditions, and a range of emerging treatments aimed at supplementing or competing with anti-VEGF agents are being developed. We will discuss the proposed merits these emerging agents bring to the treatment arsenal and how they compare with anti-VEGFs with regards to therapeutic activity, potency, specificity and safety. This review will also highlight recent pre-clinical research findings and suggest where future research might be directed. © Springer-Verlag 2010.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s00109-010-0709-z
dc.sourceScopus
dc.subjectAge-related macular degeneration (AMD)
dc.subjectAnti-VEGF
dc.subjectDiabetic retinopathy (DR)
dc.subjectNeuronal degeneration
dc.subjectRetinal angiogenesis
dc.subjectRetinal edema
dc.typeReview
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1007/s00109-010-0709-z
dc.description.sourcetitleJournal of Molecular Medicine
dc.description.volume89
dc.description.issue4
dc.description.page343-361
dc.description.codenJMLME
dc.identifier.isiut000289689200004
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