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Title: Emerging therapeutic approaches in the management of retinal angiogenesis and edema
Authors: Truong, A.
Wong, T.Y. 
Khachigian, L.M.
Keywords: Age-related macular degeneration (AMD)
Diabetic retinopathy (DR)
Neuronal degeneration
Retinal angiogenesis
Retinal edema
Issue Date: Apr-2011
Citation: Truong, A., Wong, T.Y., Khachigian, L.M. (2011-04). Emerging therapeutic approaches in the management of retinal angiogenesis and edema. Journal of Molecular Medicine 89 (4) : 343-361. ScholarBank@NUS Repository.
Abstract: Conditions resulting in retinal angiogenesis and edema (exudative age-related macular degeneration, diabetic retinopathy, retinal vein occlusion and retinopathy of prematurity) are major causes of visual impairment, with significant impact on quality of life. There has been increasing clinical usage of anti-vascular endothelial growth factor (anti-VEGF) agents to stop retinal angiogenesis and resolve intraretinal fluid arising from these conditions. However, anti-VEGFs have not been completely successful in curing these conditions, and a range of emerging treatments aimed at supplementing or competing with anti-VEGF agents are being developed. We will discuss the proposed merits these emerging agents bring to the treatment arsenal and how they compare with anti-VEGFs with regards to therapeutic activity, potency, specificity and safety. This review will also highlight recent pre-clinical research findings and suggest where future research might be directed. © Springer-Verlag 2010.
Source Title: Journal of Molecular Medicine
ISSN: 09462716
DOI: 10.1007/s00109-010-0709-z
Appears in Collections:Staff Publications

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