Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2010.10.025
DC FieldValue
dc.titleMolecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer
dc.contributor.authorKannaiyan, R.
dc.contributor.authorShanmugam, M.K.
dc.contributor.authorSethi, G.
dc.date.accessioned2014-11-26T07:50:04Z
dc.date.available2014-11-26T07:50:04Z
dc.date.issued2011-04-01
dc.identifier.citationKannaiyan, R., Shanmugam, M.K., Sethi, G. (2011-04-01). Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer. Cancer Letters 303 (1) : 9-20. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2010.10.025
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109796
dc.description.abstractIdentification of active constituents and their molecular targets from traditional medicine is an enormous opportunity for modern pharmacology. Celastrol is one such compound that was originally identified from traditional Chinese medicine (Thunder of God Vine) almost three decades ago and generally used for the treatment of inflammatory and auto-immune diseases. Celastrol has attracted great interest recently, especially for its potential anti-inflammatory and anti-cancer activities. The anti-inflammatory effects of this triterpene have been demonstrated in animal models of different inflammatory diseases, including arthritis, Alzheimer's disease, asthma, and systemic lupus erythematosus. This triterpene has also been found to inhibit the proliferation of a variety of tumor cells and suppress tumor initiation, promotion and metastasis in various cancer models in vivo. Celastrol's ability to modulate the expression of pro-inflammatory cytokines, MHC II, HO-1, iNOS, NF-κB, Notch-1, AKT/mTOR, CXCR4, TRAIL receptors DR4 and DR5, CHOP, JNK, VEGF, adhesion molecules, proteasome activity, topoisomerase II, potassium channels, and heat shock response has been reported. This review describes the various molecular targets of celastrol, cellular responses to celastrol, and animal studies with celastrol in cancer and other inflammatory disorders. © 2010 Elsevier Ireland Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.canlet.2010.10.025
dc.sourceScopus
dc.subjectAngiogenesis
dc.subjectCancer
dc.subjectCelastrol
dc.subjectInflammatory disorders
dc.subjectMetastasis
dc.typeOthers
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.canlet.2010.10.025
dc.description.sourcetitleCancer Letters
dc.description.volume303
dc.description.issue1
dc.description.page9-20
dc.description.codenCALED
dc.identifier.isiut000288820100002
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