Please use this identifier to cite or link to this item:
Title: DNA methyltransferases and TETs in the regulation of differentiation and invasiveness of extra-villous trophoblasts
Authors: Logan, P.C.
Mitchell, M.D.
Lobie, P.E. 
Keywords: Cell differentiation
Chromatin condensation
DNA methyltransferases
Issue Date: 2013
Citation: Logan, P.C.,Mitchell, M.D.,Lobie, P.E. (2013). DNA methyltransferases and TETs in the regulation of differentiation and invasiveness of extra-villous trophoblasts. Frontiers in Genetics 4 (DEC) : -. ScholarBank@NUS Repository.
Abstract: Specialized cell types of trophoblast cells form the placenta in which each cell type has particular properties of proliferation and invasion. The placenta sustains the growth of the fetus throughout pregnancy and any aberrant trophoblast differentiation or invasion potentially affects the future health of the child and adult. Recently, the field of epigenetics has been applied to understand differentiation of trophoblast lineages and embryonic stem cells (ESC), from fertilization of the oocyte onward. Each trophoblast cell-type has a distinctive epigenetic profile and we will concentrate on the epigenetic mechanism of DNA methyltransferases and TETs that regulate DNA methylation. Environmental factors affecting the mother potentially regulate the DNA methyltransferases in trophoblasts, and so do steroid hormones, cell cycle regulators, such as p53, and cytokines, especially interlukin-1β. There are interesting questions of why trophoblast genomes are globally hypomethylated yet specific genes can be suppressed by hypermethylation (in general, tumor suppressor genes, such as E-cadherin) and how invasive cell-types are liable to have condensed chromatin, as in metastatic cancer cells. Future work will attempt to understand the interactive nature of all epigenetic mechanisms together and their effect on the complex biological system of trophoblast differentiation and invasion in normal as well as pathological conditions. © 2013 Logan, Mitchell and Lobie.
Source Title: Frontiers in Genetics
ISSN: 16648021
DOI: 10.3389/fgene.2013.00265
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 30, 2023

Page view(s)

checked on Jan 26, 2023

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.