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Title: α - synuclein and Parkinson's disease: The first roadblock
Authors: Lin Chua, C.E.
Tang, B.L. 
Keywords: α-synuclein
Endoplasmic reticulum
Membrane traffic
Parkinson's disease
Issue Date: Oct-2006
Citation: Lin Chua, C.E., Tang, B.L. (2006-10). α - synuclein and Parkinson's disease: The first roadblock. Journal of Cellular and Molecular Medicine 10 (4) : 828-837. ScholarBank@NUS Repository.
Abstract: α-synuclein gene mutations are major underlying genetic defects known in familial juvenile onset Parkinson's disease (PD), and α-synuclein is a major constituent of Lewy Bodies, the pathological hallmark of PD. The normal cellular function of α-synuclein has been elusive, and its exact etiological mechanism in causing dopaminergic neuronal death in PD is also not clearly understood. Very recent reports now indicate that mutant or simply over-expressed α-synuclein could cause damage by interfering with particular steps of neuronal membrane traffic. α-synuclein selectively blocks endoplamic reticulum-to-Golgi transport, thus causing ER stress. A screen in a yeast revealed that α-synuclein toxicity could be suppressed by over-expression of the small GTPase Ypt1/Rab1, and that over-expression of the latter rescues neuron loss in invertebrate and mammalian models of α-synuclein-induced neurodegeneration. α-synuclein may also serve a chaperone function for the proper folding of synaptic SNAREs that are important for neurotransmitter release. We discuss these recent results and the emerging pathophysiological interaction of α-synuclein with components of neuronal membrane traffic.
Source Title: Journal of Cellular and Molecular Medicine
ISSN: 15821838
DOI: 10.2755/jcmm010.004.04
Appears in Collections:Staff Publications

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