Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ydbio.2008.09.002
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dc.titleWnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture
dc.contributor.authorChen, Y.
dc.contributor.authorStump, R.J.W.
dc.contributor.authorLovicu, F.J.
dc.contributor.authorShimono, A.
dc.contributor.authorMcAvoy, J.W.
dc.date.accessioned2014-11-26T07:49:26Z
dc.date.available2014-11-26T07:49:26Z
dc.date.issued2008-12-01
dc.identifier.citationChen, Y., Stump, R.J.W., Lovicu, F.J., Shimono, A., McAvoy, J.W. (2008-12-01). Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Developmental Biology 324 (1) : 161-176. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ydbio.2008.09.002
dc.identifier.issn00121606
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109738
dc.description.abstractHow an organ develops its characteristic shape is a major issue. This is particularly critical for the eye lens as its function depends on having appropriately ordered three-dimensional cellular architecture. Recent in vitro studies indicate that Wnt signaling plays key roles in regulating morphological events in FGF-induced fiber cell differentiation in the mammalian lens. To further investigate this the Wnt signaling antagonist, secreted frizzled-related protein 2 (Sfrp2), was overexpressed in lens fiber cells of transgenic mice. In these mice fiber cell elongation was attenuated and individual fibers exhibited irregular shapes and consequently did not align or pack regularly; microtubules, microfilaments and intermediate filaments were clearly disordered in these fibers. Furthermore, a striking feature of transgenic lenses was that fibers did not develop the convex curvature typically seen in normal lenses. This appears to be related to a lack of protrusive processes that are required for directed migratory activity at their apical and basal tips as well as for the formation of interlocking processes along their lateral margins. Components of the Wnt/Planar Cell Polarity (PCP) pathway were downregulated or inhibited. Taken together this supports a role for Wnt/PCP signaling in orchestrating the complex organization and dynamics of the fiber cell cytoskeleton. © 2008 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ydbio.2008.09.002
dc.sourceScopus
dc.subjectFrizzled
dc.subjectLens cell cytoskeleton
dc.subjectLens development
dc.subjectLens fibers
dc.subjectPlanar cell polarity
dc.subjectRho GTPases
dc.subjectSecreted frizzled-related proteins
dc.subjectWnt signaling
dc.typeArticle
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.description.doi10.1016/j.ydbio.2008.09.002
dc.description.sourcetitleDevelopmental Biology
dc.description.volume324
dc.description.issue1
dc.description.page161-176
dc.description.codenDEBIA
dc.identifier.isiut000261837200016
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