Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2012.12.012
Title: Trefoil factor 1 suppression of E-CADHERIN enhances prostate carcinoma cell invasiveness and metastasis
Authors: Bougen, N.M.
Amiry, N.
Yuan, Y.
Kong, X.J.
Pandey, V.
Vidal, L.J.P.
Perry, J.K.
Zhu, T.
Lobie, P.E. 
Keywords: Epithelial-to-mesenchymal transition
Metastasis
Prostate cancer
Trefoil factor 1
Issue Date: 10-May-2013
Citation: Bougen, N.M., Amiry, N., Yuan, Y., Kong, X.J., Pandey, V., Vidal, L.J.P., Perry, J.K., Zhu, T., Lobie, P.E. (2013-05-10). Trefoil factor 1 suppression of E-CADHERIN enhances prostate carcinoma cell invasiveness and metastasis. Cancer Letters 332 (1) : 19-29. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2012.12.012
Abstract: Metastasis is the primary mediator of prostate cancer (PCA) lethality and poses a significant clinical obstacle. The identification of factors involved in the metastasis of PCA is imperative. We demonstrate herein that trefoil factor 1 (TFF1) promotes PCA cell migration and invasion in vitro and metastasis in vivo. The capacity of TFF1 to enhance cell migration/invasion is mediated by transcriptional repression of E-CADHERIN. Consideration of targeted inhibition of TFF1 to prevent metastasis of prostate carcinoma is warranted. © 2012 Elsevier Ireland Ltd.
Source Title: Cancer Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/109718
ISSN: 03043835
DOI: 10.1016/j.canlet.2012.12.012
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