Please use this identifier to cite or link to this item: https://doi.org/10.1159/000321387
Title: Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects
Authors: Sng, C.C.A.
Cackett, P.D.
Yeo, I.Y.
Thalamuthu, A.
Venkatraman, A.
Venkataraman, D.
Koh, A.H.
Tai, E.-S.
Wong, T.Y. 
Aung, T.
Vithana, E.N.
Keywords: Age-related macular degeneration
Choroidal neovascularization
Genetics
Toll-like receptor
Issue Date: Apr-2011
Citation: Sng, C.C.A., Cackett, P.D., Yeo, I.Y., Thalamuthu, A., Venkatraman, A., Venkataraman, D., Koh, A.H., Tai, E.-S., Wong, T.Y., Aung, T., Vithana, E.N. (2011-04). Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects. Ophthalmic Research 45 (4) : 191-196. ScholarBank@NUS Repository. https://doi.org/10.1159/000321387
Abstract: Background/Aims: Age-related macular degeneration (AMD) is a leading cause of visual impairment. A single-nucleotide polymorphism (SNP; rs3775291) in the Toll-like receptor 3 (TLR3) gene has recently been implicated in the pathogenesis of AMD in Caucasian populations. The aim of this study was to examine this association in Chinese persons with choroidal neovascularization (CNV) secondary to AMD and polypoidal choroidal vasculopathy (PCV). Methods: This was an observational cross-sectional study in Singapore. Study subjects were of Chinese ethnicity and included patients with exudative maculopathy and normal control subjects. The diagnoses of CNV and PCV were made based on fundus examination, fluorescein angiography and indocyanine green angiography findings. Genomic DNA was extracted, and genotypes were determined by bidirectional DNA sequencing. We compared the allele and genotype frequencies between subjects with CNV and PCV with controls using the software PLINK. Results: A total of 246 subjects with exudative maculopathy (consisting of 126 with CNV and 120 with PCV) and 274 normal control subjects were recruited. The distribution of rs3775291 SNP genotypes for CNV and PCV was not significantly different from that for normal controls. Conclusion: This study indicates that the TLR3 rs3775291 gene polymorphism is not associated with CNV and PCV in Singaporean Chinese patients. Copyright © 2010 S. Karger AG, Basel.
Source Title: Ophthalmic Research
URI: http://scholarbank.nus.edu.sg/handle/10635/109715
ISSN: 00303747
DOI: 10.1159/000321387
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

13
checked on May 14, 2021

WEB OF SCIENCETM
Citations

12
checked on May 14, 2021

Page view(s)

93
checked on May 17, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.