Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.08-2822
Title: The relationship of intraocular pressure with age, systolic blood pressure, and central corneal thickness in an Asian population
Authors: Wong, T.T.
Wong, T.Y. 
Foster, P.J.
Crowston, J.G.
Fong, C.-W.
Aung, T.
Issue Date: 2009
Citation: Wong, T.T., Wong, T.Y., Foster, P.J., Crowston, J.G., Fong, C.-W., Aung, T. (2009). The relationship of intraocular pressure with age, systolic blood pressure, and central corneal thickness in an Asian population. Investigative Ophthalmology and Visual Science 50 (9) : 4097-4102. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.08-2822
Abstract: PURPOSE. To describe the distribution of intraocular pressure (IOP) and its cross-sectional relationship to age, systolic blood pressure (sBP), and central corneal thickness (CCT) in an Asian population. METHODS. This was a population-based, cross-sectional study of 3280 Malay subjects (78.7% response) aged 40 to 80 years residing in Singapore. The participants had a standardized interview, examination, and ocular imaging at a centralized study clinic. IOP was measured with Goldmann applanation tonometry (GAT) before pupil dilation, CCT measurements were obtained with an ultrasound pachymeters, and sBP was taken with participants seated after 5 minutes of rest with an automatic blood pressure monitor. RESULTS. IOP increased with age to the sixth decade, after which a decrease in IOP was seen with further increase in age, resulting in an inverted U pattern. sBP increased linearly with age whereas CCT decreased linearly with age. In regression models, age, CCT, and sBP were all significant determinants of IOP (P < 0.001 for all three). In younger persons aged 40 to 59 years, both CCT and sBP were positively associated with IOP (P < 0.001 for both), but in older persons of 60 to 80 years, only age and sBP had a positive association with of IOP (P = 0.001 for age, P < 0.001 for sBP). CONCLUSIONS. Age, CCT and sBP are significant determinants of IOP in persons aged 40 to 80 years, with CCT being a more important determinant in younger persons. The opposing effects of age-specific changes in sBP and CCT interact to lead to a relatively flat profile of IOP with age, possibly with a subtle inverted U-shaped relationship. © Association for Research in Vision and Ophthalmology.
Source Title: Investigative Ophthalmology and Visual Science
URI: http://scholarbank.nus.edu.sg/handle/10635/109705
ISSN: 01460404
DOI: 10.1167/iovs.08-2822
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

76
checked on Nov 25, 2022

WEB OF SCIENCETM
Citations

78
checked on Nov 17, 2022

Page view(s)

174
checked on Nov 24, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.