Please use this identifier to cite or link to this item: https://doi.org/10.1038/jhh.2011.88
Title: The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients
Authors: De Silva, D.A.
Woon, F.-P.
Manzano, J.J.F.
Liu, E.Y.
Chang, H.-M.
Chen, C.
Wang, J.J.
Mitchell, P.
Kingwell, B.A.
Cameron, J.D.
Lindley, R.I.
Wong, T.Y. 
Wong, M.-C.
Keywords: ischemic stroke
large-artery stiffness
retinal microvasculature
Issue Date: Dec-2012
Citation: De Silva, D.A., Woon, F.-P., Manzano, J.J.F., Liu, E.Y., Chang, H.-M., Chen, C., Wang, J.J., Mitchell, P., Kingwell, B.A., Cameron, J.D., Lindley, R.I., Wong, T.Y., Wong, M.-C. (2012-12). The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients. Journal of Human Hypertension 26 (12) : 716-722. ScholarBank@NUS Repository. https://doi.org/10.1038/jhh.2011.88
Abstract: Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 acute ischemic stroke patients in Singapore who had aortic stiffness measurements using carotid-femoral pulse wave velocity (cPWV). Retinal photographs were assessed for retinal microvessel caliber and qualitative signs of focal arteriolar narrowing, arteriovenous nicking and enhanced arteriolar light reflex. Aortic stiffening was associated with retinal arteriolar changes. Retinal arteriolar caliber decreased with increasing cPWV (r=-0.207, P=0.014). After adjusting for age, gender, hypertension, diabetes, mean arterial pressure and small-vessel stroke subtype, patients within the highest cPWV quartile were more likely to have generalized retinal arteriolar narrowing defined as lowest caliber tertile (odds ratio (OR) 6.84, 95% confidence interval (CI) 1.45-32.30), focal arteriolar narrowing (OR 13.85, CI 1.82-105.67), arteriovenous nicking (OR 5.08, CI 1.12-23.00) and enhanced arteriolar light reflex (OR 3.83, CI 0.89-16.48), compared with those within the lowest quartile. In ischemic stroke patients, aortic stiffening is associated with retinal arteriolar luminal narrowing as well as features of retinal arteriolosclerosis. © 2012 Macmillan Publishers Limited. All rights reserved.
Source Title: Journal of Human Hypertension
URI: http://scholarbank.nus.edu.sg/handle/10635/109701
ISSN: 09509240
DOI: 10.1038/jhh.2011.88
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

14
checked on Sep 16, 2021

WEB OF SCIENCETM
Citations

13
checked on Sep 8, 2021

Page view(s)

92
checked on Sep 16, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.