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Title: The association of aspirin use with age-related macular degeneration
Authors: Liew, G.
Mitchell, P.
Wong, T.Y. 
Rochtchina, E.
Wang, J.J.
Issue Date: 25-Feb-2013
Citation: Liew, G., Mitchell, P., Wong, T.Y., Rochtchina, E., Wang, J.J. (2013-02-25). The association of aspirin use with age-related macular degeneration. JAMA Internal Medicine 173 (4) : 258-264. ScholarBank@NUS Repository.
Abstract: Objective: To determine whether regular aspirin use is associated with a higher risk for developing agerelated macular degeneration (AMD) by using analyzed data from a 15-year prospective cohort. Methods: A prospective analysis was conducted of data from an Australian population-based cohort with 4 examinations during a 15-year period (1992-1994 to 2007-2009). Participants completed a detailed questionnaire at baseline assessing aspirin use, cardiovascular disease status, and AMD risk factors. Age-related macular degeneration was graded side-by-side from retinal photographs taken at each study visit to assess the incidence of neovascular (wet) AMD and geographic atrophy (dry AMD) according to the international AMD classification. Results: Of 2389 baseline participants with follow-up data available, 257 individuals (10.8%) were regular aspirin users and 63 of the 2389 developed neovascular AMD. Persons who were regular aspirin users were more likely to have incident neovascular AMD: the 15-year cumulative incidence was 9.3% in users and 3.7% in nonusers. After adjustment for age, sex, smoking, history of cardiovascular disease, systolic blood pressure, and body mass index, persons who were regular aspirin users had a higher risk of developing neovascular AMD (odds ratio [OR], 2.46; 95% CI, 1.25-4.83). The association showed a dose-response effect (multivariate-adjusted P=.01 for trend). Aspirin use was not associated with the incidence of geographic atrophy (multivariate-adjusted OR, 0.99; 95% CI, 0.59-1.65). Conclusion: Regular aspirin use is associated with increased risk of incident neovascular AMD, independent of a history of cardiovascular disease and smoking. © 2013 American Medical Association. All rights reserved.
Source Title: JAMA Internal Medicine
ISSN: 21686106
DOI: 10.1001/jamainternmed.2013.1583
Appears in Collections:Staff Publications

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