Please use this identifier to cite or link to this item: https://doi.org/10.1002/ijc.22345
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dc.titleSecond malignancies among survivors of germ-cell testicular cancer: A pooled analysis between 13 cancer registries
dc.contributor.authorRichiardi, L.
dc.contributor.authorScélo, G.
dc.contributor.authorBoffetta, P.
dc.contributor.authorHemminki, K.
dc.contributor.authorPukkala, E.
dc.contributor.authorOlsen, J.H.
dc.contributor.authorWeiderpass, E.
dc.contributor.authorTracey, E.
dc.contributor.authorBrewster, D.H.
dc.contributor.authorMcBride, M.L.
dc.contributor.authorKliewer, E.V.
dc.contributor.authorTonita, J.M.
dc.contributor.authorPompe-Kirn, V.
dc.contributor.authorKee-Seng, C.
dc.contributor.authorJonasson, J.G.
dc.contributor.authorMartos, C.
dc.contributor.authorBrennan, P.
dc.date.accessioned2014-11-26T07:48:17Z
dc.date.available2014-11-26T07:48:17Z
dc.date.issued2007-02-01
dc.identifier.citationRichiardi, L., Scélo, G., Boffetta, P., Hemminki, K., Pukkala, E., Olsen, J.H., Weiderpass, E., Tracey, E., Brewster, D.H., McBride, M.L., Kliewer, E.V., Tonita, J.M., Pompe-Kirn, V., Kee-Seng, C., Jonasson, J.G., Martos, C., Brennan, P. (2007-02-01). Second malignancies among survivors of germ-cell testicular cancer: A pooled analysis between 13 cancer registries. International Journal of Cancer 120 (3) : 623-631. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.22345
dc.identifier.issn00207136
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109642
dc.description.abstractWe investigated the risk of second malignancies among 29,511 survivors of germ-cell testicular cancer recorded in 13 cancer registries. Standardized incidence ratios (SIRs) were estimated comparing the observed numbers of second malignancies with the expected numbers obtained from sex-, age-, period- and population-specific incidence rates. Seminomas and nonseminomas, the 2 main histological groups of testicular cancer, were analyzed separately. During a median follow-up period of 8.3 years (0-35 years), we observed 1,811 second tumors, with a corresponding SIR of 1.65 (95% confidence interval (CI): 1.57-1.73). Statistically significant increased risks were found for fifteen cancer types, including SIRs of 2.0 or higher for cancers of the stomach, gallbladder and bile ducts, pancreas, bladder, kidney, thyroid, and for soft-tissue sarcoma, nonmelanoma skin cancer and myeloid leukemia. The SIR for myeloid leukemia was 2.39 (95% CI: 1.41-3.77) after seminomas, and 6.77 (95% CI: 4.14-10.5) after nonseminomas. It increased to 37.9 (95% CI: 18.9-67.8; based on 11 observed cases of leukemia) among nonseminoma patients diagnosed since 1990. SIRs for most solid cancers increased with follow-up duration, whereas they did not change with year of testicular cancer diagnosis. Among subjects diagnosed before 1980, 20 year survivors of seminoma had a cumulative risk of solid cancer of 9.6% (95% CI: 8.7-10.5%) vs. 6.5% expected, whereas 20 years survivors of non-seminoma had a risk of 5.0% (95% CI: 4.2-6.0%) vs. 3.1% expected. In conclusion, survivors of testicular cancers have an increased risk of several second primaries, where the effect of the treatment seems to play a major role. © 2006 Wiley-Liss, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/ijc.22345
dc.sourceScopus
dc.subjectChemotherapy
dc.subjectLeukaemia
dc.subjectNonseminoma
dc.subjectRadiotherapy
dc.subjectSeminomas
dc.subjectSurvival
dc.subjectTesticular cancer
dc.subjectTreatment
dc.typeArticle
dc.contributor.departmentCOMMUNITY,OCCUPATIONAL & FAMILY MEDICINE
dc.description.doi10.1002/ijc.22345
dc.description.sourcetitleInternational Journal of Cancer
dc.description.volume120
dc.description.issue3
dc.description.page623-631
dc.description.codenIJCNA
dc.identifier.isiut000242869000022
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