Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ygyno.2011.04.044
Title: RUNX3 functions as an oncogene in ovarian cancer
Authors: Lee, C.W.L. 
Chuang, L.S.H. 
Kimura, S. 
Lai, S.K. 
Ong, C.W. 
Yan, B.
Salto-Tellez, M. 
Choolani, M.
Ito, Y.
Keywords: Ovarian cancer
RUNX3
Issue Date: Aug-2011
Citation: Lee, C.W.L., Chuang, L.S.H., Kimura, S., Lai, S.K., Ong, C.W., Yan, B., Salto-Tellez, M., Choolani, M., Ito, Y. (2011-08). RUNX3 functions as an oncogene in ovarian cancer. Gynecologic Oncology 122 (2) : 410-417. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ygyno.2011.04.044
Abstract: Objective: The Runt domain transcription factor, RUNX3, has been shown to be a tumor suppressor in a variety of cancers including gastric, colon and breast cancer. Interestingly, an oncogenic role for RUNX3 has also been suggested in basal cell carcinoma and head and neck cancer. Here, we explore the role of RUNX3 in ovarian cancer. Methods: Expression of RUNX3 mRNA and protein was evaluated in human ovarian cancer cell lines. In addition, subcellular localization of RUNX3 was also examined in cell lines and ovarian cancer tissues. Effect of exogenous RUNX3 expression and knockdown on cell proliferation was investigated by proliferation assays and a soft agar assay. Results: Expression of RUNX3 was detected in the nucleus of ovarian cancer cell lines and ovarian cancer tissues and was found to play a growth stimulatory role. RUNX3 knockdown resulted in a decrease in cell proliferation in liquid media as well as in soft agar. Despite the fact that exogenous expression of RUNX3 strongly inhibits cell growth in many cell types, RUNX3 promoted cell growth in ovarian cancer cell lines not expressing RUNX3. Conclusion: RUNX3 is frequently expressed in the nuclei of ovarian cancer cell lines and plays an oncogenic role in ovarian cancer. © 2011 Elsevier Inc.
Source Title: Gynecologic Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/109636
ISSN: 00908258
DOI: 10.1016/j.ygyno.2011.04.044
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

41
checked on Sep 17, 2019

WEB OF SCIENCETM
Citations

40
checked on Sep 17, 2019

Page view(s)

73
checked on Sep 20, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.