Please use this identifier to cite or link to this item: https://doi.org/10.1615/ForumImmunDisTher.2013008382
DC FieldValue
dc.titleRole of NF-κB in tumorigenesis
dc.contributor.authorShanmugam, M.K.
dc.contributor.authorKumar, A.P.
dc.contributor.authorTan, B.K.H.
dc.contributor.authorSethi, G.
dc.date.accessioned2014-11-26T07:48:13Z
dc.date.available2014-11-26T07:48:13Z
dc.date.issued2013
dc.identifier.citationShanmugam, M.K.,Kumar, A.P.,Tan, B.K.H.,Sethi, G. (2013). Role of NF-κB in tumorigenesis. Forum on Immunopathological Diseases and Therapeutics 4 (2) : 181-196. ScholarBank@NUS Repository. <a href="https://doi.org/10.1615/ForumImmunDisTher.2013008382" target="_blank">https://doi.org/10.1615/ForumImmunDisTher.2013008382</a>
dc.identifier.issn21518017
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109635
dc.description.abstractPersistent activation of the pro-inflammatory transcription factor nuclear factor-κB (NF-κB) is frequently observed in several human malignancies and can drive the processes of tumor initiation, oncogenic transformation, and malignant progression. Once activated, this master transcription factor regulates the expression of numerous genes involved in proliferation, survival, metastasis, angiogenesis, chemoresistance, and radioresistance. Thus, novel pharmacological agents that can suppress constitutive and/or inducible NF-κB activation have the potential for cancer therapy. In this review, we describe in detail the pleiotropic molecular mechanisms of aberrant NF-κB activation and also discuss various therapeutic strategies employed to suppress deregulated activation of this important oncogenic transcription factor in cancer. © 2013 by Begell House, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1615/ForumImmunDisTher.2013008382
dc.sourceScopus
dc.subjectAngiogenesis
dc.subjectApoptosis
dc.subjectCancer
dc.subjectInflammation
dc.subjectNF-κB
dc.subjectProliferation
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1615/ForumImmunDisTher.2013008382
dc.description.sourcetitleForum on Immunopathological Diseases and Therapeutics
dc.description.volume4
dc.description.issue2
dc.description.page181-196
dc.identifier.isiutNOT_IN_WOS
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