Please use this identifier to cite or link to this item:
|Title:||Role of NF-κB in tumorigenesis||Authors:||Shanmugam, M.K.
|Issue Date:||2013||Citation:||Shanmugam, M.K.,Kumar, A.P.,Tan, B.K.H.,Sethi, G. (2013). Role of NF-κB in tumorigenesis. Forum on Immunopathological Diseases and Therapeutics 4 (2) : 181-196. ScholarBank@NUS Repository. https://doi.org/10.1615/ForumImmunDisTher.2013008382||Abstract:||Persistent activation of the pro-inflammatory transcription factor nuclear factor-κB (NF-κB) is frequently observed in several human malignancies and can drive the processes of tumor initiation, oncogenic transformation, and malignant progression. Once activated, this master transcription factor regulates the expression of numerous genes involved in proliferation, survival, metastasis, angiogenesis, chemoresistance, and radioresistance. Thus, novel pharmacological agents that can suppress constitutive and/or inducible NF-κB activation have the potential for cancer therapy. In this review, we describe in detail the pleiotropic molecular mechanisms of aberrant NF-κB activation and also discuss various therapeutic strategies employed to suppress deregulated activation of this important oncogenic transcription factor in cancer. © 2013 by Begell House, Inc.||Source Title:||Forum on Immunopathological Diseases and Therapeutics||URI:||http://scholarbank.nus.edu.sg/handle/10635/109635||ISSN:||21518017||DOI:||10.1615/ForumImmunDisTher.2013008382|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 29, 2022
checked on Nov 24, 2022
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.