Please use this identifier to cite or link to this item: https://doi.org/10.1615/ForumImmunDisTher.2013008382
Title: Role of NF-κB in tumorigenesis
Authors: Shanmugam, M.K. 
Kumar, A.P. 
Tan, B.K.H.
Sethi, G.
Keywords: Angiogenesis
Apoptosis
Cancer
Inflammation
NF-κB
Proliferation
Issue Date: 2013
Citation: Shanmugam, M.K.,Kumar, A.P.,Tan, B.K.H.,Sethi, G. (2013). Role of NF-κB in tumorigenesis. Forum on Immunopathological Diseases and Therapeutics 4 (2) : 181-196. ScholarBank@NUS Repository. https://doi.org/10.1615/ForumImmunDisTher.2013008382
Abstract: Persistent activation of the pro-inflammatory transcription factor nuclear factor-κB (NF-κB) is frequently observed in several human malignancies and can drive the processes of tumor initiation, oncogenic transformation, and malignant progression. Once activated, this master transcription factor regulates the expression of numerous genes involved in proliferation, survival, metastasis, angiogenesis, chemoresistance, and radioresistance. Thus, novel pharmacological agents that can suppress constitutive and/or inducible NF-κB activation have the potential for cancer therapy. In this review, we describe in detail the pleiotropic molecular mechanisms of aberrant NF-κB activation and also discuss various therapeutic strategies employed to suppress deregulated activation of this important oncogenic transcription factor in cancer. © 2013 by Begell House, Inc.
Source Title: Forum on Immunopathological Diseases and Therapeutics
URI: http://scholarbank.nus.edu.sg/handle/10635/109635
ISSN: 21518017
DOI: 10.1615/ForumImmunDisTher.2013008382
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