Please use this identifier to cite or link to this item: https://doi.org/10.1038/sj.bjc.6605616
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dc.titleRisks of second primary cancer among patients with major histological types of lung cancers in both men and women
dc.contributor.authorChuang, S.-C.
dc.contributor.authorScélo, G.
dc.contributor.authorLee, Y.-C.A.
dc.contributor.authorFriis, S.
dc.contributor.authorPukkala, E.
dc.contributor.authorBrewster, D.H.
dc.contributor.authorHemminki, K.
dc.contributor.authorTracey, E.
dc.contributor.authorWeiderpass, E.
dc.contributor.authorTamaro, S.
dc.contributor.authorPompe-Kirn, V.
dc.contributor.authorKliewer, E.V.
dc.contributor.authorChia, K.-S.
dc.contributor.authorTonita, J.M.
dc.contributor.authorMartos, C.
dc.contributor.authorJonasson, J.G.
dc.contributor.authorBoffetta, P.
dc.contributor.authorBrennan, P.
dc.contributor.authorHashibe, M.
dc.date.accessioned2014-11-26T07:48:11Z
dc.date.available2014-11-26T07:48:11Z
dc.date.issued2010-03
dc.identifier.citationChuang, S.-C., Scélo, G., Lee, Y.-C.A., Friis, S., Pukkala, E., Brewster, D.H., Hemminki, K., Tracey, E., Weiderpass, E., Tamaro, S., Pompe-Kirn, V., Kliewer, E.V., Chia, K.-S., Tonita, J.M., Martos, C., Jonasson, J.G., Boffetta, P., Brennan, P., Hashibe, M. (2010-03). Risks of second primary cancer among patients with major histological types of lung cancers in both men and women. British Journal of Cancer 102 (7) : 1190-1195. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.bjc.6605616
dc.identifier.issn00070920
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109632
dc.description.abstractBackground:Patterns of second primary cancers (SPCs) following first primary lung cancers (FPLCs) may provide aetiological insights into FPLC.Methods:Cases of FPLCs in 13 cancer registries in Europe, Australia, Canada, and Singapore were followed up from the date of FPLC diagnosis to the date of SPC diagnosis, date of death, or end of follow-up. Standardised incidence ratios (SIRs) were calculated to estimate the magnitude of SPC development following squamous cell carcinoma (SCC), small cell lung carcinoma (SCLC), and adenocarcinoma (ADC).Results:Among SCC patients, male SIR1.58 (95% confidence interval (CI)1.50-1.66) and female SIR2.31 (1.94-2.72) for smoking-related SPC. Among SCLC patients, the respective ratios were 1.39 (1.20-1.60) and 2.28 (1.73-2.95), and among ADC patients, they were 1.73 (1.57-1.90) and 2.24 (1.91-2.61). We also observed associations between first primary lung ADC and second primary breast cancer in women (SIR1.25, 95% CI1.05-1.48) and prostate cancer (1.56, 1.39-1.79) in men.Conclusion:The FPLC patients carried excess risks of smoking-related SPCs. An association between first primary lung ADC and second primary breast and ovarian cancer in women at younger age and prostate cancers in men may reflect an aetiological role of hormones in lung ADC. © 2010 Cancer Research UK All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/sj.bjc.6605616
dc.sourceScopus
dc.subjectLung cancer
dc.subjectSex differences
dc.subjectSPCs
dc.typeArticle
dc.contributor.departmentEPIDEMIOLOGY & PUBLIC HEALTH
dc.description.doi10.1038/sj.bjc.6605616
dc.description.sourcetitleBritish Journal of Cancer
dc.description.volume102
dc.description.issue7
dc.description.page1190-1195
dc.description.codenBJCAA
dc.identifier.isiut000276159900016
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