Please use this identifier to cite or link to this item: https://doi.org/10.1038/sj.bjc.6605616
Title: Risks of second primary cancer among patients with major histological types of lung cancers in both men and women
Authors: Chuang, S.-C.
Scélo, G.
Lee, Y.-C.A.
Friis, S.
Pukkala, E.
Brewster, D.H.
Hemminki, K.
Tracey, E.
Weiderpass, E.
Tamaro, S.
Pompe-Kirn, V.
Kliewer, E.V.
Chia, K.-S. 
Tonita, J.M.
Martos, C.
Jonasson, J.G.
Boffetta, P.
Brennan, P.
Hashibe, M.
Keywords: Lung cancer
Sex differences
SPCs
Issue Date: Mar-2010
Citation: Chuang, S.-C., Scélo, G., Lee, Y.-C.A., Friis, S., Pukkala, E., Brewster, D.H., Hemminki, K., Tracey, E., Weiderpass, E., Tamaro, S., Pompe-Kirn, V., Kliewer, E.V., Chia, K.-S., Tonita, J.M., Martos, C., Jonasson, J.G., Boffetta, P., Brennan, P., Hashibe, M. (2010-03). Risks of second primary cancer among patients with major histological types of lung cancers in both men and women. British Journal of Cancer 102 (7) : 1190-1195. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.bjc.6605616
Abstract: Background:Patterns of second primary cancers (SPCs) following first primary lung cancers (FPLCs) may provide aetiological insights into FPLC.Methods:Cases of FPLCs in 13 cancer registries in Europe, Australia, Canada, and Singapore were followed up from the date of FPLC diagnosis to the date of SPC diagnosis, date of death, or end of follow-up. Standardised incidence ratios (SIRs) were calculated to estimate the magnitude of SPC development following squamous cell carcinoma (SCC), small cell lung carcinoma (SCLC), and adenocarcinoma (ADC).Results:Among SCC patients, male SIR1.58 (95% confidence interval (CI)1.50-1.66) and female SIR2.31 (1.94-2.72) for smoking-related SPC. Among SCLC patients, the respective ratios were 1.39 (1.20-1.60) and 2.28 (1.73-2.95), and among ADC patients, they were 1.73 (1.57-1.90) and 2.24 (1.91-2.61). We also observed associations between first primary lung ADC and second primary breast cancer in women (SIR1.25, 95% CI1.05-1.48) and prostate cancer (1.56, 1.39-1.79) in men.Conclusion:The FPLC patients carried excess risks of smoking-related SPCs. An association between first primary lung ADC and second primary breast and ovarian cancer in women at younger age and prostate cancers in men may reflect an aetiological role of hormones in lung ADC. © 2010 Cancer Research UK All rights reserved.
Source Title: British Journal of Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/109632
ISSN: 00070920
DOI: 10.1038/sj.bjc.6605616
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

17
checked on Nov 30, 2020

WEB OF SCIENCETM
Citations

16
checked on Nov 30, 2020

Page view(s)

66
checked on Nov 28, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.