Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.11-7689
Title: Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD
Authors: Wickremasinghe, S.S.
Busija, L.
Guymer, R.H.
Wong, T.Y. 
Qureshi, S.
Issue Date: Jan-2012
Citation: Wickremasinghe, S.S., Busija, L., Guymer, R.H., Wong, T.Y., Qureshi, S. (2012-01). Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD. Investigative Ophthalmology and Visual Science 53 (1) : 37-41. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.11-7689
Abstract: PURPOSE. To examine whether baseline retinal vascular caliber predicts visual response to intravitreal ranibizumab injections in patients with neovascular age-related macular degeneration (AMD). METHODS. In this prospective cohort study, patients with neovascular AMD received three monthly intravitreal injections of ranibizumab, followed by as needed dosing up to 1 year. Retinal vascular caliber was measured from digital fundus photographs at baseline and summarized as central retinal artery equivalent (CRAE) and venular equivalent (CRVE), representing average caliber of arterioles and venules, respectively. Visual outcome at 12 months was assessed and the relation to baseline retinal vascular caliber was determined. RESULTS. A total of 88 eyes were analyzed at baseline. After accounting for age, sex, size of choroidal neovascularization, and number of injections, patients who deteriorated in visual acuity at 12 months had significantly larger baseline CRVE, 243.10 μm (95% confidence interval [CI], 227.01-259.19), compared with those who were stable, 214.30 μm (95% CI, 205.79-222.81) and those who improved, 215.26 μm (95% CI, 204.69-225.84; P = 0.007). Baseline CRAE did not differ significantly from eyes whose vision deteriorated, 150.12 μm (95% CI, 140.67-159.57), compared with those remaining stable, 143.64 μm (95% CI, 138.64-148.63), or gaining vision 142.92 μm (95% CI, 136.71-149.13; P = 0.69). CONCLUSIONS. In eyes with neovascular AMD treated with intravitreal ranibizumab, larger baseline retinal venular caliber was significantly associated with a poorer response to treatment, possibly reflecting increased disease severity. © 2012 The Association for Research in Vision and Ophthalmology, Inc.
Source Title: Investigative Ophthalmology and Visual Science
URI: http://scholarbank.nus.edu.sg/handle/10635/109614
ISSN: 01460404
DOI: 10.1167/iovs.11-7689
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

11
checked on Sep 22, 2021

WEB OF SCIENCETM
Citations

11
checked on Sep 22, 2021

Page view(s)

78
checked on Sep 23, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.