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Title: Retinal microvascular abnormalities and cognitive function in latino adults in Los Angeles
Authors: Gatto, N.M.
Varma, R.
Torres, M.
Wong, T.Y. 
Johnson, P.L.
Segal-Gidan, F.
MacK, W.J.
Keywords: Cognition
Issue Date: Jun-2012
Citation: Gatto, N.M., Varma, R., Torres, M., Wong, T.Y., Johnson, P.L., Segal-Gidan, F., MacK, W.J. (2012-06). Retinal microvascular abnormalities and cognitive function in latino adults in Los Angeles. Ophthalmic Epidemiology 19 (3) : 127-136. ScholarBank@NUS Repository.
Abstract: Purpose: Retinal vessels may provide a readily accessible surrogate approach to study vascular disease in brain small vessels. Previous epidemiologic studies of retinal microvascular abnormalities and cognition have not included large numbers of Latinos who have a high prevalence of diabetes and hypertension. Methods: We used data from 809 elderly Latino participants in the Los Angeles Latino Eye Study (LALES) to assess whether retinal vessel caliber and microvascular abnormalities are cross-sectionally associated with lower cognitive function. Cognitive screening was conducted with the Cognitive Abilities Screening Instrument-Short form (CASI-S) and in-depth testing with the Spanish English Neuropsychological Assessment Scales (SENAS). Retinal photographs were used to identify retinopathy signs and measure retinal vessel caliber. Results: A total of 65.8% had high blood pressure, 34.5% had diabetes; self-reported diagnoses of heart attack, heart failure, angina and stroke were rare. Retinal calibers and any retinopathy were not associated with the CASI-S, total SENAS or any SENAS cognitive factors assessed as continuous variables. The odds of a low CASI-S score were two times higher in subjects with generalized arteriolar narrowing (OR=2.04, 95% CI=1.14, 3.66), and one and half times as high in those with both generalized arteriolar narrowing and retinopathy signs (OR=1.49, 95% CI=0.47, 4.75) though this result was based on only four cases with both risk factors and confidence limits were wide and included the null. Conclusion: Retinal microvasculature imaging may provide insights into small blood vessel influences on cognition in Latino populations. Additional studies in diverse populations and prospective settings are needed. © 2012 Informa Healthcare USA, Inc.
Source Title: Ophthalmic Epidemiology
ISSN: 09286586
DOI: 10.3109/09286586.2011.615452
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