Please use this identifier to cite or link to this item: https://doi.org/10.1002/jnr.20731
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dc.titleReorganization of CA3 area of the mouse hippocampus after pilocarpine induced temporal lobe epilepsy with special reference to the CA3-septum pathway
dc.contributor.authorMa, D.L.
dc.contributor.authorTang, Y.C.
dc.contributor.authorChen, P.M.
dc.contributor.authorChia, S.C.
dc.contributor.authorJiang, F.L.
dc.contributor.authorBurgunder, J.-M.
dc.contributor.authorLee, W.L.
dc.contributor.authorTang, F.R.
dc.date.accessioned2014-11-26T07:47:42Z
dc.date.available2014-11-26T07:47:42Z
dc.date.issued2006-02-01
dc.identifier.citationMa, D.L., Tang, Y.C., Chen, P.M., Chia, S.C., Jiang, F.L., Burgunder, J.-M., Lee, W.L., Tang, F.R. (2006-02-01). Reorganization of CA3 area of the mouse hippocampus after pilocarpine induced temporal lobe epilepsy with special reference to the CA3-septum pathway. Journal of Neuroscience Research 83 (2) : 318-331. ScholarBank@NUS Repository. https://doi.org/10.1002/jnr.20731
dc.identifier.issn03604012
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109590
dc.description.abstractWe showed that when CA3 pyramidal neurons in the caudal 80% of the dorsal hippocampus had almost disappeared completely, the efferent pathway of CA3 was rarely detectable. We used the mouse pilocarpine model of temporal lobe epilepsy (TLE), and injected iontophoretically the anterograde tracer phaseolus vulgaris leucoagglutinin (PHA-L) into gliotic CA3, medial septum and the nucleus of diagonal band of Broca, median raphe, and lateral supramammillary nuclei, or the retrograde tracer cholera toxin B subunit (CTB) into gliotic CA3 area of hippocampus. In the afferent pathway, the number of neurons projecting to CA3 from medial septum and the nucleus of diagonal band of Broca, median raphe, and lateral supramammillary nuclei increased significantly. In the hippocampus, where CA3 pyramidal neurons were partially lost, calbindin, calretinin, parvalbumin immunopositive back-projection neurons from CA1-CA3 area were observed. Sprouting of Schaffer collaterals with increased number of large boutons in both sides of CA1 area, particularly in the stratum pyramidale, was found. When CA3 pyramidal neurons in caudal 80% of the dorsal hippocampus have almost disappeared completely, surviving CA3 neurons in the rostral 20% of the dorsal hippocampus may play an important role in transmitting hyperactivity of granule cells to surviving CA1 neurons or to dorsal part of the lateral septum. We concluded that reorganization of CA3 area with its downstream or upstream nuclei may be involved in the occurrence of epilepsy. © 2005 Wiley-Liss, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jnr.20731
dc.sourceScopus
dc.subjectCA3 area
dc.subjectEpilepsy
dc.subjectHippocampus
dc.subjectMouse
dc.subjectReorganization
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.doi10.1002/jnr.20731
dc.description.sourcetitleJournal of Neuroscience Research
dc.description.volume83
dc.description.issue2
dc.description.page318-331
dc.description.codenJNRED
dc.identifier.isiut000235434300016
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