Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.09-3878
Title: Relationship between retinal structures and retinal vessel caliber in normal adolescents
Authors: Samarawickrama, C.
Huynh, S.C.
Wang, J.J.
Pai, A.
Joachim, N.
Burlutsky, G.
Wong, T.Y. 
Mitchell, P.
Issue Date: Dec-2009
Citation: Samarawickrama, C., Huynh, S.C., Wang, J.J., Pai, A., Joachim, N., Burlutsky, G., Wong, T.Y., Mitchell, P. (2009-12). Relationship between retinal structures and retinal vessel caliber in normal adolescents. Investigative Ophthalmology and Visual Science 50 (12) : 5619-5624. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.09-3878
Abstract: Purpose. To describe the normal physiological relationship between retinal arteriolar and venular caliber and retinal nerve fiber layer (RNFL), macular, and optic nerve head parameters. Methods. The Sydney Childhood Eye Study assessed 2038 adolescents aged 12 years. Retinal vessel calibers were measured from digital fundus photographs using standardized protocols. Optical coherence tomography measurements of RNFL, macular, and optic nerve head parameters were obtained with the Fast-scan protocol of the Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA). Mixed model analyses were performed. Results. After adjustment for covariates, each micrometer increase in RNFL thickness was associated with a 0.22-fxm (0.15%, P < 0.0001) and 0.49-fxm (0.23%, P < 0.0001) increase in mean arteriolar and venular caliber, respectively. This positive association existed across all RNFL quadrants (0.07%-0.24%, P < 0.002). Each micrometer increase in macular thickness (inner/outer) and cubic millimeter increase in macular volume was associated with a 0.12/0.15-fxm (0.08%-0.10%, P < 0.0001) and 5.31-fxm (3.53%, P < 0.0001) increase in mean arteriolar caliber and a 0.22/0.31-fxm (0.10%- 0.15%, P < 0.0001) and 10.95-fxm (5.08%, P < 0.0001) increase in mean venular caliber, respectively. Finally, each millimeter increase in vertical optic disc diameter and each square millimeter increase in optic disc area was associated with a 2.83-fxm (1.88%, P = 0.02) and 2.02-fxm (1.35%, P = 0.01) increase in mean retinal arteriolar caliber and a 5.73-fxm (2.66%, P = 0.001) and 5.02-fxm (2.33%, P < 0.0001) increase in mean retinal venular diameter, respectively. Conclusions. In normal adolescent retinas, thicker RNFL and macula parameters and larger optic discs correlate with larger retinal vascular caliber. Understanding these normal anatomic relationships is essential for determining their significance in studying the vascular etiology of ocular and systemic diseases.© Association for Research in Vision and Ophthalmology.
Source Title: Investigative Ophthalmology and Visual Science
URI: http://scholarbank.nus.edu.sg/handle/10635/109578
ISSN: 01460404
DOI: 10.1167/iovs.09-3878
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

21
checked on Nov 30, 2022

WEB OF SCIENCETM
Citations

19
checked on Nov 30, 2022

Page view(s)

172
checked on Nov 24, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.