Please use this identifier to cite or link to this item: https://doi.org/10.3892/etm.2011.254
Title: Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma
Authors: Wu, W.-Y.
Li, J.
Wu, Z.-S.
Zhang, C.-L.
Meng, X.-L.
Lobie, P.E. 
Keywords: Hepatocellular carcinoma
Phosphorylated signal transducer and activator of transcription 3
Prognosis
Suppressor of cytokine signaling 3
Issue Date: Jul-2011
Citation: Wu, W.-Y., Li, J., Wu, Z.-S., Zhang, C.-L., Meng, X.-L., Lobie, P.E. (2011-07). Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma. Experimental and Therapeutic Medicine 2 (4) : 647-653. ScholarBank@NUS Repository. https://doi.org/10.3892/etm.2011.254
Abstract: Altered expression of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) and suppressor of cytokine signaling 3 (SOCS3) has been implicated in various types of human cancers. However, the clinical role of pSTAT3 and SOCS3 in hepatocellular carcinoma (HCC) is not well established. Immunohistochemical analysis of pSTAT3, SOCS3, Ki67 and VEGF expression was performed on tissue microarrays from 138 HCC patients. The expression of STAT3 mRNA was further detected by in situ hybridization. The association of pSTAT3 and SOCS3 expression with clinico-pathological factors and patient survival was analyzed. Altered expression of pSTAT3 and SOCS3 was observed in HCC specimens, compared to adjacent non-tumor tissue. Increased expression of pSTAT3 was correlated with large tumor size, higher clinical stage, Ki67 and VEGF expression, as well as poor patient survival. Decreased expression of SOCS3 was correlated with the expression of Ki67, VEGF and pSTAT3, and poor patient survival. Moreover, the expression of pSTAT3 was conversely correlated with SOCS3 expression in HCC. Our results indicate that deregulated expression of pSTAT3 and SOCS3 may play roles in the development and progression of HCC. PSTAT3 and SOCS3 should be further evaluated as potential novel biomarkers for HCC prognosis.
Source Title: Experimental and Therapeutic Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/109549
ISSN: 17920981
DOI: 10.3892/etm.2011.254
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

19
checked on Nov 18, 2022

WEB OF SCIENCETM
Citations

16
checked on Nov 18, 2022

Page view(s)

157
checked on Nov 24, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.