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Title: Pretreatment with intravitreal triamcinolone before laser for diabetic macular edema: 6-month results of a randomized, placebo-controlled trial
Authors: Gillies, M.C.
McAllister, I.L.
Zhu, M.
Wong, W.
Louis, D.
Arnold, J.J.
Wong, T.Y. 
Issue Date: May-2010
Citation: Gillies, M.C., McAllister, I.L., Zhu, M., Wong, W., Louis, D., Arnold, J.J., Wong, T.Y. (2010-05). Pretreatment with intravitreal triamcinolone before laser for diabetic macular edema: 6-month results of a randomized, placebo-controlled trial. Investigative Ophthalmology and Visual Science 51 (5) : 2322-2328. ScholarBank@NUS Repository.
Abstract: Purpose. To determine whether pretreatment with intravitreal triamcinolone acetonide (IVTA) before laser photocoagulation is effective in eyes with diabetic macular edema (DME). Methods. The study was a prospective, double-masked, placebo- controlled, clinical trial of eyes with DME and impaired vision (≤20/40) randomized to IVTA 4 mg versus placebo 6 weeks before laser treatment. The main outcome measure was the proportion of eyes with improvement of best-corrected logarithm of minimum angle of resolution (logMAR) visual acuity of ≥5 letters after 6 months. Secondary outcomes were necessity of further treatment, change in central macular thickness, and incidence of adverse events. Results. Eighty-four eyes of 54 participants were entered into the study, with 6-month data available for 81 (96%) of 84 eyes. Improvement of ≥5 logMAR letters was similar in eyes treated with IVTA before laser as placebo (18/42 [43%] IVTA vs. 16/34 [38%] laser alone; P=0.807), as were retreatment rates at 6 months (22 [56%] IVTA vs. 21 [53%] laser alone; P=0.727). Mean central macular thickness decreased by 50 μm (95% confidence interval, 10-96 μm) more in the IVTA treatment group than in the laser-alone group after 6 months (P=0.016). Glaucoma therapy was necessary more frequently in IVTAtreated eyes than in those treated with laser alone (19/42 [45%] vs. 7/42 [17%]; P=0.005). Conclusions. Visual results and the need for further laser treatment at 6 months were no better in the IVTA group than in the laser-alone group, despite a better anatomic outcome reflected by reduction in mean central macular thickness. This study found no evidence of a synergistic effect of IVTA and laser photocoagulation for DME. © Association for Research in Vision and Ophthalmology.
Source Title: Investigative Ophthalmology and Visual Science
ISSN: 01460404
DOI: 10.1167/iovs.09-4400
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