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https://doi.org/10.1016/j.chroma.2013.11.025
Title: | Preparation and characterization of 4-isopropylcalix[4]arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography | Authors: | Chelvi, S.K.T. Zhao, J. Chen, L. Yan, S. Yin, X. Sun, J. Yong, E.L. Wei, Q. Gong, Y. |
Keywords: | β-Cyclodextrin 4-Isopropylcalix[4]arene, Chiral separation Chiral stationary phase High-performance liquid chromatography |
Issue Date: | 10-Jan-2014 | Citation: | Chelvi, S.K.T., Zhao, J., Chen, L., Yan, S., Yin, X., Sun, J., Yong, E.L., Wei, Q., Gong, Y. (2014-01-10). Preparation and characterization of 4-isopropylcalix[4]arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography. Journal of Chromatography A 1324 : 104-108. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2013.11.025 | Abstract: | A new type of 4-isopropylcalix[4]arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)propylsilyl-appended silica particles (IPC4CD-HPS) has been prepared by treatment of bromoacetate-substituted (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)propylsilyl-appended silica particles (BACD-HPS) with 4-isopropylcalix[4]arene oxyanions in anhydrous N-methyl-2-pyrrolidone. The bonded silica IPC4CD-HPS has been successfully used as chiral stationary phase (CSP) in high-performance liquid chromatography (HPLC) for the first time. The synthetic stationary phase was characterized by means of elemental analysis and Fourier transform infrared spectroscopy. This new CSP has a chiral selector with two anchored functional moieties: 4-isopropylcalix[4]arene and β-cyclodextrin. The chromatographic performance of IPC4CD-HPS was investigated by separation of positional isomers of several disubstituted benzenes and enantiomers of some chiral drug compounds under reversed-phase conditions. The results showed that IPC4CD-HPS had excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds due to the cooperative functioning of the anchored 4-isopropylcalix[4]arenes and β-cyclodextrins. © 2013 Elsevier B.V. | Source Title: | Journal of Chromatography A | URI: | http://scholarbank.nus.edu.sg/handle/10635/109530 | ISSN: | 00219673 | DOI: | 10.1016/j.chroma.2013.11.025 |
Appears in Collections: | Staff Publications |
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