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|Title:||Preparation and characterization of 4-isopropylcalixarene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography||Authors:||Chelvi, S.K.T.
4-Isopropylcalixarene, Chiral separation
Chiral stationary phase
High-performance liquid chromatography
|Issue Date:||10-Jan-2014||Citation:||Chelvi, S.K.T., Zhao, J., Chen, L., Yan, S., Yin, X., Sun, J., Yong, E.L., Wei, Q., Gong, Y. (2014-01-10). Preparation and characterization of 4-isopropylcalixarene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography. Journal of Chromatography A 1324 : 104-108. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2013.11.025||Abstract:||A new type of 4-isopropylcalixarene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)propylsilyl-appended silica particles (IPC4CD-HPS) has been prepared by treatment of bromoacetate-substituted (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)propylsilyl-appended silica particles (BACD-HPS) with 4-isopropylcalixarene oxyanions in anhydrous N-methyl-2-pyrrolidone. The bonded silica IPC4CD-HPS has been successfully used as chiral stationary phase (CSP) in high-performance liquid chromatography (HPLC) for the first time. The synthetic stationary phase was characterized by means of elemental analysis and Fourier transform infrared spectroscopy. This new CSP has a chiral selector with two anchored functional moieties: 4-isopropylcalixarene and β-cyclodextrin. The chromatographic performance of IPC4CD-HPS was investigated by separation of positional isomers of several disubstituted benzenes and enantiomers of some chiral drug compounds under reversed-phase conditions. The results showed that IPC4CD-HPS had excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds due to the cooperative functioning of the anchored 4-isopropylcalixarenes and β-cyclodextrins. © 2013 Elsevier B.V.||Source Title:||Journal of Chromatography A||URI:||http://scholarbank.nus.edu.sg/handle/10635/109530||ISSN:||00219673||DOI:||10.1016/j.chroma.2013.11.025|
|Appears in Collections:||Staff Publications|
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