Please use this identifier to cite or link to this item:
|Title:||Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers||Authors:||Lim, W.-Y.
|Issue Date:||Apr-2011||Citation:||Lim, W.-Y., Chen, Y., Ali, S.M., Chuah, K.L., Eng, P., Leong, S.S., Lim, E., Lim, T.K., Ng, A.W., Poh, W.T., Tee, A., Teh, M., Salim, A., Seow, A. (2011-04). Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers. Carcinogenesis 32 (4) : 522-529. ScholarBank@NUS Repository. https://doi.org/10.1093/carcin/bgr006||Abstract:||Inflammation appears to be important in lung carcinogenesis among smokers, but its role among never-smokers is not well established. We hypothesized that inflammatory medical conditions and gene polymorphisms interact to increase lung cancer risk in never-smokers. We interviewed 433 Singaporean female neversmoker lung cancer patients and 1375 hospital controls, and evaluated six polymorphisms in the interleukin 1-β, interleukin 6 (IL6), cyclooxygenase-2, peroxisome proliferator-activated receptor-γ and interleukin 1-β receptor antagonist (IL1RN) genes. Tuberculosis was associated with a non-significant elevated risk of lung cancer [odds ratio (OR) 1.58, 95% confidence interval (CI) 0.95-2.62]. There was no effect of asthma, atopy or chronic productive cough individually. However, the presence of one or more of these conditions (asthma, cough or atopy) increased risk (OR 2.24, 95%CI 1.15-4.38) in individuals possessing the T/T genotype at interleukin 1-β -31T/C, but not in those possessing the C/T (OR 0.87, 95%CI 0.51-1.57) or C/C genotypes (OR 0.58, 95%CI 0.27-1.27), and in individuals having the *2 variable number of tandem repeat allele of IL1RN [OR 5.09 (1.39-18.67)], but not in those without (OR 0.93, 95%CI 0.63-1.35). The IL6-634 G allele increased the risk of lung cancer (OR 1.44, 95%CI 1.07-1.94). Lung cancer risk also increased with the number of polymorphism sites where at least 1 'risk' allele was present [interleukin 1-β -31T/C (T allele), IL1RN (*2 allele) and IL6-634C/G (G allele)] among those with asthma, cough or atopy (Ptrend 0.001) but not in those without (Ptrend 0.47). Our results suggest that the effect of inflammatory medical conditions on lung cancer in neversmokers is modulated by host genetic susceptibility and will need to be confirmed in other studies conducted in similar populations. © The Author 2011. Published by Oxford University Press. All rights reserved.||Source Title:||Carcinogenesis||URI:||http://scholarbank.nus.edu.sg/handle/10635/109522||ISSN:||01433334||DOI:||10.1093/carcin/bgr006|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 30, 2023
WEB OF SCIENCETM
checked on May 30, 2023
checked on May 25, 2023
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.