Please use this identifier to cite or link to this item:
|Title:||Plasma carotenoids and risk of acute myocardial infarction in the Singapore Chinese Health Study||Authors:||Koh, W.-P.
Nested case-control study
|Issue Date:||Sep-2011||Citation:||Koh, W.-P., Yuan, J.-M., Wang, R., Lee, Y.-P., Lee, B.-L., Yu, M.C., Ong, C.-N. (2011-09). Plasma carotenoids and risk of acute myocardial infarction in the Singapore Chinese Health Study. Nutrition, Metabolism and Cardiovascular Diseases 21 (9) : 685-690. ScholarBank@NUS Repository. https://doi.org/10.1016/j.numecd.2009.12.005||Abstract:||Background and aim: Modification of low-density lipoprotein due to oxidative stress is essential in the development of coronary atherosclerosis. Data of specific carotenoids except β-carotene on cardioprotective effects in humans are limited. Methods and results: This study examined the associations between plasma concentrations of specific carotenoids and incidence of acute myocardial infarction. The study included 280 incident cases of acute myocardial infarction and 560 matched controls nested within the Singapore Chinese Health Study, a prospective cohort of 63,257 Chinese men and women aged 45-74 years old enrolled in 1993-1998 in Singapore. Retinol and carotenoids in prediagnostic plasma were quantified using high-performance liquid chromatography. High levels of plasma β-cryptoxanthin and lutein were associated with decreased risk of acute myocardial infarction after adjustment for multiple risk factors for coronary heart disease. For β-cryptoxanthin, the odds ratio (95% confidence interval) for the highest (Q5) versus the lowest (Q1) quintile was 0.67 (0.37-1.21) (P for trend. = 0.03). For lutein, the odds ratios (95% confidence intervals) for the combined Q2-Q3 and the combined Q4-Q5 versus Q1 were 0.71 (0.45-1.12) and 0.58 (0.35-0.94) respectively (P for trend. = 0.03). There was no statistically significant association between other carotenoids or retinol and risk of acute myocardial infarction. Conclusions: High plasma levels of β-cryptoxanthin and lutein were associated with decreased risk of acute myocardial infarction. The findings of this study support a cardioprotective role of these two carotenoids in humans. © 2009 Elsevier B.V.||Source Title:||Nutrition, Metabolism and Cardiovascular Diseases||URI:||http://scholarbank.nus.edu.sg/handle/10635/109519||ISSN:||09394753||DOI:||10.1016/j.numecd.2009.12.005|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 20, 2021
WEB OF SCIENCETM
checked on Oct 20, 2021
checked on Oct 14, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.