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|Title:||Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis||Authors:||Zheng, J.
|Issue Date:||9-Aug-2013||Citation:||Zheng, J., Rubin, E.J., Bifani, P., Mathys, V., Lim, V., Au, M., Jang, J., Nam, J., Dick, T., Walker, J.R., Pethe, K., Camacho, L.R. (2013-08-09). Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis. Journal of Biological Chemistry 288 (32) : 23447-23456. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.475798||Abstract:||Background: PAS is an antimycobacterial whose mechanism(s) of action remains elusive. Results: PAS is incorporated into the folate pathway by DHPS-DHFS, generating an anti-metabolite. DHFS and RibD are associated with PAS resistance. Conclusion: Hydroxyl dihydrofolate inhibits DHFR. folC and ribD are drug target genes for identification of clinical PAS resistance. Significance: Metabolite analog incorporation into essential biosynthetic pathways is promising for developing antibacterials. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.||Source Title:||Journal of Biological Chemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/109505||ISSN:||00219258||DOI:||10.1074/jbc.M113.475798|
|Appears in Collections:||Staff Publications|
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