Please use this identifier to cite or link to this item:
|Title:||Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis||Authors:||Zheng, J.
|Issue Date:||9-Aug-2013||Citation:||Zheng, J., Rubin, E.J., Bifani, P., Mathys, V., Lim, V., Au, M., Jang, J., Nam, J., Dick, T., Walker, J.R., Pethe, K., Camacho, L.R. (2013-08-09). Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis. Journal of Biological Chemistry 288 (32) : 23447-23456. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.475798||Abstract:||Background: PAS is an antimycobacterial whose mechanism(s) of action remains elusive. Results: PAS is incorporated into the folate pathway by DHPS-DHFS, generating an anti-metabolite. DHFS and RibD are associated with PAS resistance. Conclusion: Hydroxyl dihydrofolate inhibits DHFR. folC and ribD are drug target genes for identification of clinical PAS resistance. Significance: Metabolite analog incorporation into essential biosynthetic pathways is promising for developing antibacterials. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.||Source Title:||Journal of Biological Chemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/109505||ISSN:||00219258||DOI:||10.1074/jbc.M113.475798|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Apr 2, 2020
WEB OF SCIENCETM
checked on Mar 17, 2020
checked on Mar 28, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.