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Title: Novel versus traditional risk markers for diabetic retinopathy
Authors: Sasongko, M.B.
Wong, T.Y. 
Nguyen, T.T.
Shaw, J.E.
Jenkins, A.J.
Wang, J.J.
Keywords: Diabetic retinopathy
Flicker-light vasodilation
Microvascular function
Retinal vascular tortuosity
Serum apolipoproteins
Skin iontophoresis
Issue Date: Mar-2012
Citation: Sasongko, M.B., Wong, T.Y., Nguyen, T.T., Shaw, J.E., Jenkins, A.J., Wang, J.J. (2012-03). Novel versus traditional risk markers for diabetic retinopathy. Diabetologia 55 (3) : 666-670. ScholarBank@NUS Repository.
Abstract: Aims/hypothesis: To explore the relative contribution of novel and traditional risk markers for diabetic retinopathy (DR). Methods: A clinic-based study of 224 diabetic patients (85 type 1, 139 type 2) from a diabetes clinic was performed. DR was graded from fundus photographs according to the Airlie House Classification system and classified as absent or present (at least ETDRS level 14). Novel risk markers assessed included serum apolipoprotein (Apo) AI and B, skin microvascular responses to acetylcholine (endothelium-dependent) and sodium nitroprusside (endothelium-independent) iontophoresis, flicker-light-induced retinal vasodilation and retinal vascular tortuosity. Relative contribution was determined by semi-partial correlation coefficient generated from a logistic regression model containing all traditional and novel risk markers simultaneously. Results: There were 144 (64.3%) participants with DR. Of the novel markers, ApoAI, flicker-light-induced vasodilation and retinal arteriolar tortuosity were significantly associated with DR, independently of traditional measures (all p
Source Title: Diabetologia
ISSN: 0012186X
DOI: 10.1007/s00125-011-2424-x
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