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https://doi.org/10.1016/j.febslet.2011.05.042
Title: | MiR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway | Authors: | Tan, S. Li, R. Ding, K. Lobie, P.E. Zhu, T. |
Keywords: | c-MET Hepatocellular carcinoma Invasion miR-198 |
Issue Date: | 21-Jul-2011 | Citation: | Tan, S., Li, R., Ding, K., Lobie, P.E., Zhu, T. (2011-07-21). MiR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway. FEBS Letters 585 (14) : 2229-2234. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2011.05.042 | Abstract: | Metastasis is the leading cause of death in patients with hepatocellular carcinoma (HCC) and microRNAs have been implicated to influence this process. Emerging evidence indicates that miR-198 is down-regulated in HCC compared to normal liver parenchyma, but the functional roles of miR-198 in HCC cells remains unexplored. Herein, we show that miR-198 directly targets c-MET via its 3′UTR. Forced expression of miR-198 decreased c-MET expression at both mRNA and protein levels and consequently diminished HGF induced phosphorylation of p44/42 MAPK in HCC cells. Forced expression of miR-198 inhibited HGF promotion of HCC cell migration and invasion in a c-MET dependent manner. In conclusion, we have identified miR-198 as a novel suppressor of HCC cell invasion by negative regulation of the HGF/c-MET pathway. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | Source Title: | FEBS Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/109468 | ISSN: | 00145793 | DOI: | 10.1016/j.febslet.2011.05.042 |
Appears in Collections: | Staff Publications |
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