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Title: Lung cancer mortality risk among breast cancer patients treated with anti-estrogens
Authors: Bouchardy, C.
Benhamou, S.
Schaffar, R.
Verkooijen, H.M. 
Fioretta, G.
Schubert, H.
Vinh-Hung, V.
Soria, J.-C.
Vlastos, G.
Rapiti, E.
Keywords: anti-estrogens
breast cancer
lung cancer
mortality risk
population-based study
Issue Date: 15-Mar-2011
Citation: Bouchardy, C., Benhamou, S., Schaffar, R., Verkooijen, H.M., Fioretta, G., Schubert, H., Vinh-Hung, V., Soria, J.-C., Vlastos, G., Rapiti, E. (2011-03-15). Lung cancer mortality risk among breast cancer patients treated with anti-estrogens. Cancer 117 (6) : 1288-1295. ScholarBank@NUS Repository.
Abstract: BACKGROUND: The Women's Health Initiative randomized clinical trial reported that menopausal hormone therapy increases lung cancer mortality risk. If this is true, use of anti-estrogens should be associated with decreased lung cancer mortality risk. The authors compared lung cancer incidence and mortality among breast cancer patients with and without anti-estrogen therapy. METHODS: Our study included all 6655 women diagnosed with breast cancer between 1980 and 2003 and registered at the Geneva Cancer Registry. Among these women, 46% (3066) received anti-estrogens. All women were followed for occurrence and death from lung cancer until December 2007. The authors compared incidence and mortality rates among patients with and without anti-estrogens with those expected in the general population by Standardized Incidence Ratios (SIRs) and Standardized Mortality Ratios (SMRs). RESULTS: After a total of 57,257 person-years, 40 women developed lung cancer. SIRs for lung cancer were not significantly decreased among breast cancer patients with and without anti-estrogens (0.63, 95% confidence intervals [CI], 0.33-1.10; and 1.12, 95% CI, 0.74-1.62, respectively) while SMR was decreased among women with anti-estrogens (0.13, 95% CI, 0.02-0.47, P
Source Title: Cancer
ISSN: 0008543X
DOI: 10.1002/cncr.25638
Appears in Collections:Staff Publications

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