Please use this identifier to cite or link to this item:
Title: Location and membrane sources for autophagosome formation-from ER-mitochondria contact sites to Golgi-endosome-derived carriers
Authors: Chan, S.N.
Tang, B.L. 
Keywords: Autophagosome
ER-mitochondria contact sites
Issue Date: Dec-2013
Citation: Chan, S.N., Tang, B.L. (2013-12). Location and membrane sources for autophagosome formation-from ER-mitochondria contact sites to Golgi-endosome-derived carriers. Molecular Membrane Biology 30 (8) : 394-402. ScholarBank@NUS Repository.
Abstract: Recent advances have revealed much about the signaling events and molecular components associated with autophagy. Although it is clear that there are multiple points of intersection and connection between autophagy and known vesicular membrane transport processes between membrane compartments, autophagy is modulated by a distinct set of molecular components, and the autophagosome has a unique membrane composition. A key question that has yet to be resolved with regards to autophagosome formation is its membrane source. Various evidences have indicated that membranes from the endoplasmic reticulum (ER), mitochondria, Golgi, endosomes and the plasma membrane could all potentially act as a source of autophagosomal membrane in non-specialized macroautophagy. Recent investigations have generated advances in terms of the mitochondria's involvement in starvation-induced autophagy, and refined localization of autophagosome formation to ER-mitochondria contact sites. On the other hand, data accumulates on the delivery of membrane sources to the pre-autophagosome structure by Atg9-containing mobile carriers, which likely originated from the Golgi-endosome system. The answer to the question on the origin of membrane materials for autophagosome biogenesis awaits further reconciliation of these different findings. © 2013 Informa UK, Ltd.
Source Title: Molecular Membrane Biology
ISSN: 09687688
DOI: 10.3109/09687688.2013.850178
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 30, 2023


checked on Jan 30, 2023

Page view(s)

checked on Feb 2, 2023

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.