Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cellimm.2011.06.004
Title: Lactobacilli secreting a tumor antigen and IL15 activates neutrophils and dendritic cells and generates cytotoxic T lymphocytes against cancer cells
Authors: Kandasamy, M.
Bay, B.-H.
Lee, Y.-K.
Mahendran, R. 
Keywords: CTL
DC
IL-15
Lactobacillus
Neutrophils
PSA
Issue Date: 2011
Citation: Kandasamy, M., Bay, B.-H., Lee, Y.-K., Mahendran, R. (2011). Lactobacilli secreting a tumor antigen and IL15 activates neutrophils and dendritic cells and generates cytotoxic T lymphocytes against cancer cells. Cellular Immunology 271 (1) : 89-96. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cellimm.2011.06.004
Abstract: Lactobacillus rhamnosus GG (LGG) has been used to successfully induce tumor regression in an orthotopic model of bladder cancer. Increased infiltration of neutrophils and macrophages into the tumor mass was observed after therapy. This study evaluates the potential of LGG to induce a directed anti-tumor response. Lactobacilli were modified to secrete the prostate specific antigen (PSA) or IL15 and PSA (IL-15-PSA). Neutrophils and DC were exposed to LGG for 2 h as in clinical therapy for bladder cancer. Recombinant LGG activated neutrophils (elevated MHC class I expression) induced DC maturation (increased expression of CD86, CD80, CD40, MHC II and CD83), T cell proliferation and PSA specific cytotoxic T lymphocytes (CTL) activity. IL15 enhanced direct DC activation of CTL. Thus LGG secreting tumor antigens may activate antigen specific immune responses when instilled intravesically and IL15 could enhance this response. © 2011 Elsevier Inc.
Source Title: Cellular Immunology
URI: http://scholarbank.nus.edu.sg/handle/10635/109433
ISSN: 00088749
DOI: 10.1016/j.cellimm.2011.06.004
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