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Title: Is diabetic retinopathy an independent risk factor for ischemic stroke?
Authors: Cheung, N.
Rogers, S.
Couper, D.J.
Klein, R.
Sharrett, A.R.
Wong, T.Y. 
Keywords: Diabetic retinopathy
Ischemic stroke
Issue Date: Feb-2007
Citation: Cheung, N., Rogers, S., Couper, D.J., Klein, R., Sharrett, A.R., Wong, T.Y. (2007-02). Is diabetic retinopathy an independent risk factor for ischemic stroke?. Stroke 38 (2) : 398-401. ScholarBank@NUS Repository.
Abstract: BACKGROUND AND PURPOSE - The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS - A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated. RESULTS - Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86). CONCLUSIONS - Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors. © 2007 American Heart Association, Inc.
Source Title: Stroke
ISSN: 00392499
DOI: 10.1161/01.STR.0000254547.91276.50
Appears in Collections:Staff Publications

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