Please use this identifier to cite or link to this item: https://doi.org/10.1001/archgenpsychiatry.2010.176
Title: Increased mortality risk in women with depression and diabetes mellitus
Authors: Pan, A.
Lucas, M.
Sun, Q.
Van Dam, R.M. 
Franco, O.H.
Willett, W.C.
Manson, J.A.E.
Rexrode, K.M.
Ascherio, A.
Hu, F.B.
Issue Date: Jan-2011
Citation: Pan, A., Lucas, M., Sun, Q., Van Dam, R.M., Franco, O.H., Willett, W.C., Manson, J.A.E., Rexrode, K.M., Ascherio, A., Hu, F.B. (2011-01). Increased mortality risk in women with depression and diabetes mellitus. Archives of General Psychiatry 68 (1) : 42-50. ScholarBank@NUS Repository. https://doi.org/10.1001/archgenpsychiatry.2010.176
Abstract: Context: Depression and diabetes mellitus have been associated with an increased risk of all-cause and cardiovascular disease (CVD) mortality. However, data evaluating the joint effects of these 2 conditions on mortality are sparse. Objectives: To evaluate the individual and joint effects of depression and diabetes on all-cause and CVD mortality rate. Design: Prospective cohort study. Setting: The 11 states of the Nurses' Health Study. Participants: A total of 78 282 women who participated in the Nurses' Health Study aged 54 to 79 years at baseline in 2000 were followed up until 2006. Depression was defined as having self-reported diagnosed depression, treatment with antidepressant medications, or a score indicating severe depressive symptoms (ie, a 5-item Mental Health Index score≤52). Self-reported type 2 diabetes was confirmed using a supplementary questionnaire. Main Outcome Measures: All-cause and CVDspecific mortality rate. Results: During 6 years of follow-up (433 066 personyears), 4654 deaths were documented, including 979 deaths from CVD. Compared with participants without either condition, the age-adjusted relative risks (RRs) (95% confidence interval) for all-cause mortality were 1.76 (1.64- 1.89) for women with depression only, 1.71 (1.54-1.89) for individuals with diabetes only, and 3.11 (2.70-3.58) for women with both conditions. The corresponding ageadjusted RRs ofCVDmortality were 1.81 (1.54-2.13), 2.67 (2.20-3.23), and 5.38 (4.19-6.91), respectively. These associations were attenuated after multivariate adjustment for other demographic variables, body mass index, smoking status, alcohol intake, physical activity, and major comorbidities (including hypertension, hypercholesterolemia, heart diseases, stroke, and cancer) but remained significant, with the highest RRs for all-cause and CVD mortality found in those with both conditions (2.07 [1.79-2.40] and 2.72 [2.09-3.54], respectively). Furthermore, the combination of depressionwith a long duration of diabetesmellitus (ie,>10 years) or insulin therapy was associated with a particularly higher risk of CVD mortality after multivariate adjustment (RRs,3.22 and 4.90, respectively). Conclusions: Depression and diabetes are associated with a significantly increased risk of all-cause and CVD mortality rate. The coexistence of these conditions identifies women at particularly high risk. © 2011 American Medical Association. All rights reserved.
Source Title: Archives of General Psychiatry
URI: http://scholarbank.nus.edu.sg/handle/10635/109408
ISSN: 0003990X
DOI: 10.1001/archgenpsychiatry.2010.176
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

122
checked on Jan 29, 2023

WEB OF SCIENCETM
Citations

119
checked on Jan 20, 2023

Page view(s)

168
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.