Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.vaccine.2010.08.031
Title: Inactivated trivalent seasonal influenza vaccine induces limited cross-reactive neutralizing antibody responses against 2009 pandemic and 1934 PR8 H1N1 strains
Authors: Lee, V.J. 
Tay, J.K.
Chen, M.I.C.
Phoon, M.C.
Xie, M.L.
Wu, Y.
Lee, C.X.X.
Yap, J.
Sakharkar, K.R.
Sakharkar, M.K.
Lin, R.T.
Cui, L.
Kelly, P.M.
Leo, Y.S.
Tan, Y.J. 
Chow, V.T.K.
Keywords: 2009 pandemic
B-cell epitopes
Cross-reactive neutralizing antibodies
Influenza A H1N1
Seasonal influenza vaccine
Issue Date: Oct-2010
Citation: Lee, V.J., Tay, J.K., Chen, M.I.C., Phoon, M.C., Xie, M.L., Wu, Y., Lee, C.X.X., Yap, J., Sakharkar, K.R., Sakharkar, M.K., Lin, R.T., Cui, L., Kelly, P.M., Leo, Y.S., Tan, Y.J., Chow, V.T.K. (2010-10). Inactivated trivalent seasonal influenza vaccine induces limited cross-reactive neutralizing antibody responses against 2009 pandemic and 1934 PR8 H1N1 strains. Vaccine 28 (42) : 6852-6857. ScholarBank@NUS Repository. https://doi.org/10.1016/j.vaccine.2010.08.031
Abstract: Background: In June 2009, we conducted a prospective study in Singapore on 51 individuals to determine their serologic responses before and following receipt of the 2009 Southern Hemisphere seasonal influenza vaccine. Materials and methods: Paired serum samples were obtained before and 3-4 weeks after vaccination. Virus microneutralization assays were performed to quantify antibodies against A/Brisbane/59/2007 vaccine, pandemic H1N1-2009 and A/Puerto Rico/08/34 H1N1 strains. Results: Post-vaccination, 43%, 12% and 24% of subjects displayed a 4-fold or greater rise in neutralizing antibody titers against the three strains, respectively. There was a positive correlation among individuals who showed increased titers to both pandemic H1N1-2009 and A/Puerto Rico/08/34 (p
Source Title: Vaccine
URI: http://scholarbank.nus.edu.sg/handle/10635/109404
ISSN: 0264410X
DOI: 10.1016/j.vaccine.2010.08.031
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