Please use this identifier to cite or link to this item: https://doi.org/10.1093/carcin/bgn177
Title: Green tea intake, MTHFR/TYMS genotype and breast cancer risk: The Singapore Chinese Health Study
Authors: Inoue, M.
Robien, K.
Wang, R.
Van Den Berg, D.J.
Koh, W.-P. 
Yu, M.C.
Issue Date: 2008
Citation: Inoue, M., Robien, K., Wang, R., Van Den Berg, D.J., Koh, W.-P., Yu, M.C. (2008). Green tea intake, MTHFR/TYMS genotype and breast cancer risk: The Singapore Chinese Health Study. Carcinogenesis 29 (10) : 1967-1972. ScholarBank@NUS Repository. https://doi.org/10.1093/carcin/bgn177
Abstract: The tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been reported to act as a cancer preventive agent through folate pathway inhibition in experimental studies. We hypothesized that if folate pathway inhibition is the mechanism of cancer preventive activities of EGCG, then the protective effect against breast cancer would be stronger among women with low dietary folate intake and the high-activity methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) genotypes. In a nested case-control study of 380 women with incident breast cancer and 662 controls within the Singapore Chinese Health Study, we found no association between either green tea intake or gene polymorphisms of MTHFR (C677T and A1298C) and TYMS (1494 ins/del) and breast cancer risk. However, among women with low folate intake (
Source Title: Carcinogenesis
URI: http://scholarbank.nus.edu.sg/handle/10635/109374
ISSN: 01433334
DOI: 10.1093/carcin/bgn177
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

79
checked on Oct 21, 2021

WEB OF SCIENCETM
Citations

66
checked on Oct 21, 2021

Page view(s)

81
checked on Oct 14, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.