Please use this identifier to cite or link to this item:
https://doi.org/10.1093/hmg/ddt293
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dc.title | Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus | |
dc.contributor.author | Strange, A. | |
dc.contributor.author | Bellenguez, C. | |
dc.contributor.author | Sim, X. | |
dc.contributor.author | Luben, R. | |
dc.contributor.author | Hysi, P.G. | |
dc.contributor.author | Ramdas, W.D. | |
dc.contributor.author | van Koolwijk, L.M. | |
dc.contributor.author | Freeman, C. | |
dc.contributor.author | Pirinen, M. | |
dc.contributor.author | Su, Z. | |
dc.contributor.author | Band, G. | |
dc.contributor.author | Pearson, R. | |
dc.contributor.author | Vukcevic, D. | |
dc.contributor.author | Langford, C. | |
dc.contributor.author | Deloukas, P. | |
dc.contributor.author | Hunt, S. | |
dc.contributor.author | Gray, E. | |
dc.contributor.author | Dronov, S. | |
dc.contributor.author | Potter, S.C. | |
dc.contributor.author | Tashakkori-Ghanbaria, A. | |
dc.contributor.author | Edkins, S. | |
dc.contributor.author | Bumpstead, S.J. | |
dc.contributor.author | Blackwell, J.M. | |
dc.contributor.author | Bramon, E. | |
dc.contributor.author | Brown, M.A. | |
dc.contributor.author | Casas, J.P. | |
dc.contributor.author | Corvin, A. | |
dc.contributor.author | Duncanson, A. | |
dc.contributor.author | Jankowski, J.A. | |
dc.contributor.author | Markus, H.S. | |
dc.contributor.author | Mathew, C.G. | |
dc.contributor.author | Palmer, C.N. | |
dc.contributor.author | Plomin, R. | |
dc.contributor.author | Rautanen, A. | |
dc.contributor.author | Sawcer, S.J. | |
dc.contributor.author | Trembath, R.C. | |
dc.contributor.author | Wood, N.W. | |
dc.contributor.author | Barroso, I. | |
dc.contributor.author | Leena Peltonen, L.P. | |
dc.contributor.author | Healey, P. | |
dc.contributor.author | McGuffin, P. | |
dc.contributor.author | Topouzis, F. | |
dc.contributor.author | Klaver, C.C. | |
dc.contributor.author | van Duijn, C.M. | |
dc.contributor.author | Mackey, D.A. | |
dc.contributor.author | Young, T.L. | |
dc.contributor.author | Hammond, C.J. | |
dc.contributor.author | Khaw, K.-T. | |
dc.contributor.author | Wareham, N. | |
dc.contributor.author | Wang, J.J. | |
dc.contributor.author | Wong, T.Y. | |
dc.contributor.author | Foster, P.J. | |
dc.contributor.author | Mitchell, P. | |
dc.contributor.author | Spencer, C.C. | |
dc.contributor.author | Donnelly, P. | |
dc.contributor.author | Viswanathan, A.C. | |
dc.date.accessioned | 2014-11-26T07:44:59Z | |
dc.date.available | 2014-11-26T07:44:59Z | |
dc.date.issued | 2013-11 | |
dc.identifier.citation | Strange, A., Bellenguez, C., Sim, X., Luben, R., Hysi, P.G., Ramdas, W.D., van Koolwijk, L.M., Freeman, C., Pirinen, M., Su, Z., Band, G., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S., Gray, E., Dronov, S., Potter, S.C., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, S.J., Blackwell, J.M., Bramon, E., Brown, M.A., Casas, J.P., Corvin, A., Duncanson, A., Jankowski, J.A., Markus, H.S., Mathew, C.G., Palmer, C.N., Plomin, R., Rautanen, A., Sawcer, S.J., Trembath, R.C., Wood, N.W., Barroso, I., Leena Peltonen, L.P., Healey, P., McGuffin, P., Topouzis, F., Klaver, C.C., van Duijn, C.M., Mackey, D.A., Young, T.L., Hammond, C.J., Khaw, K.-T., Wareham, N., Wang, J.J., Wong, T.Y., Foster, P.J., Mitchell, P., Spencer, C.C., Donnelly, P., Viswanathan, A.C. (2013-11). Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus. Human Molecular Genetics 22 (22) : 4653-4660. ScholarBank@NUS Repository. https://doi.org/10.1093/hmg/ddt293 | |
dc.identifier.issn | 09646906 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/109365 | |
dc.description.abstract | To discover quantitative trait loci for intraocular pressure, amajor risk factor for glaucoma and the only modifiable one,weperformed agenome-wide association studyonadiscoverycohort of2175individualsfromSydney, Australia. We found a novel association between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1. The findings in this region were confirmed through two UK replication cohorts totalling 4866 individuals (rs59072263, Pcombined = 1.10 × 10-8). A copy of the G allele at this SNP is associated with an increase in mean IOP of 0.45 mmHg (95%CI = 0.30-0.61 mmHg). These results lend support to the implication of vesicle trafficking and glucocorticoid inducibility pathways in the determination of intraocular pressure and in the pathogenesis of primary open-angle glaucoma. © The Author 2013. Published by Oxford University Press. All rights reserved. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | LIFE SCIENCES INSTITUTE | |
dc.contributor.department | OPHTHALMOLOGY | |
dc.description.doi | 10.1093/hmg/ddt293 | |
dc.description.sourcetitle | Human Molecular Genetics | |
dc.description.volume | 22 | |
dc.description.issue | 22 | |
dc.description.page | 4653-4660 | |
dc.description.coden | HMGEE | |
dc.identifier.isiut | 000326675300017 | |
Appears in Collections: | Staff Publications |
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